Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-25-Adh cells, cell variants derived from S49 mouse lymphoma, were transduced with a retrovirus containing the human MDR1 cDNA.
|
7786606 |
1995 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fourteen hydantoin derivatives were synthesized and studied for their capacity to increase accumulation of ethidium bromide (EB) by mouse lymphoma cancer cells that were transfected with the human ABCB1 gene and overexpress the human ABCB1 pump.
|
22351672 |
2012 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Drug accumulation was measured in a human ABCB1 gene-transfected mouse lymphoma cell line and in a human lung cancer cell line by flow cytometry; furthermore, their anticancer effects were determined in mice in vivo.
|
22287739 |
2012 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compounds <b>1</b>-<b>3</b> were evaluated for their P-glycoprotein (P-gp/ABCB1) modulation ability, using a mouse T-lymphoma <i>MDR1</i>-transfected cell model by the rhodamine-123 accumulation assay, and displayed potent multidrug resistance (MDR)-reversing activity.
|
31339732 |
2019 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Forty cultured human leukemia and lymphoma cell lines never exposed to anticancer agents in culture, apart from doxorubicin (ADM)-resistant K562/ADM, were examined for reactivity with a monoclonal antibody, MRK16 in F(ab')2 form [MRK16-F(ab')2], which recognizes P-glycoprotein (P-gp).
|
2575608 |
1989 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To explore the possibility of using anti-B4-bR in combination with chemotherapy protocols, we investigated the in vitro and in vivo cytotoxic effects of combining it with doxorubicin or etoposide using the lymphoma cell line Namalwa and a P-glycoprotein-expressing cell line, Namalwa/mdr-1, obtained by retroviral infection of Namalwa cells with the mdr-1 gene.
|
7492789 |
1995 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of MDR-1 substrate drugs has not yet been tested as all patients remain in clinical and radiological remission of their lymphoma.
|
9614561 |
1998 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neither codeinone nor morphine inhibited P-glycoprotein-mediated rhodamine-123 efflux in multidrug resistant mouse T lymphoma L5178 transfected with human MDR 1 gene.
|
12017290 |
2002 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their biological activities were evaluated in vitro using parental (PAR) and multidrug resistant (MDR; ABCB1-overexpressing) mouse T-lymphoma cells.
|
29970523 |
2018 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, novel metal [Zn(II), Cu(II), Mg(II), Ni(II), Pd(II), and Ag(I)] complexes of 2-trifluoroacetonylbenzoxazole previously synthesized and characterized by our group were tested for their MDR-reversing activity in comparison with the free ligands in L5178Y mouse T-lymphoma (MDR) cells transfected with human ATP-binding cassette sub-family B member 1 (ABCB1; P-glycoprotein) gene.
|
30396935 |
2018 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
For this, we determined the ABCB1 inhibiting properties of our compounds in a mouse T-lymphoma cell line model and then evaluated the drug-enhancing properties of selected compounds in a co-application with clofazimine in our Mtb strain.
|
31398786 |
2019 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compounds 1-25 were evaluated for their effects on the reversion of multidrug resistance (MDR) in cancer cells mediated by P-glycoprotein (P-gp/ABCB1), through combination of functional and chemosensitivity assays, using a human ABCB1-transfected mouse T-lymphoma cell model.
|
28189906 |
2017 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDR1 has been the most studied in hematological malignancies, particularly in lymphoma and multiple myeloma (MM), diseases generally considered as overexpressing such mechanisms in relapse.
|
8520514 |
1995 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apoptosis induction and the interaction between epirubicin and the silicon-substituted compounds were studied in human MDR-1 gene-transfected mouse lymphoma and its parent cell line, Colo320/MDR-LRP and sensitive subline Colo205, by means of rhodamine 123 accumulation.
|
15161039 |
2004 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells.
|
20393003 |
2010 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to extend knowledge about pharmacophoric features responsible for ABCB1 inhibitory properties of imidazolidin-2,4-dione derivatives, 1'-[4-(4-(o-methoxyphenyl)-piperazin-1-yl)butyl]-3'-methyl-spiro(fluoren-9,5'-imidazolidine)-2',4'-dione (3) and its salt (4) with rhodanine-3-acetic acid (RA) were prepared and investigated by X-ray diffraction method, as well as their efflux modulating effects in cancer cells (mouse T-lymphoma), cytotoxic and antiproliferative activities were evaluated in vitro.
|
30586228 |
2019 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
When coupled with an anti-CD19 targeted antibody, this formulation was also effective at delivering an MDR1 asODN to a multidrug-resistant human B-lymphoma cell line in vitro, decreasing the activity of P-glycoprotein.
|
10766353 |
2000 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the exact relationship between ROS and P-gp in EBV-positive lymphoma remains unclear.
|
30972167 |
2019 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro.
|
25862866 |
2015 |
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Compounds 1-14 were evaluated for their MDR-reversing activity on human ABCB1 gene transfected mouse lymphoma cells (L5178Y-MDR) through a combination of functional and chemosensitivity assays.
|
30199257 |
2018 |
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression and activity of P-gp on NK cells derived from three normal donors, six patients with indolent NK cell-lineage granular lymphocyte-proliferative disorder (NK-GLPD), three patients with aggressive NK cell tumors (one NK cell leukemia and two nasal NK cell lymphoma), and two NK cell lines.
|
9885221 |
1999 |
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The ability of phenothiazine derivatives to inhibit the transport activity of P-glycoprotein in resistant mouse lymphoma and MDR/COLO 320 cells was studied.
|
16277030 |
2005 |
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
De novo MDR1 transcript expression was independent of response to therapy in dogs with lymphoma.
|
9568108 |
1998 |
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of our study was to establish a lymphoma, cellular system where a de novo acquisition of multidrug resistance is specifically related to overexpression of a transgenic, human MDR1.
|
15725475 |
2005 |
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There is an increased incidence of de-novo MDR-1 expression in AIDS-related lymphoma compared with lymphoma in the non-HIV settings.
|
16093797 |
2005 |