|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We cannot exclude an association of ABCB1 variants on P-gp function, but our results suggest that brain ABCB1 mRNA and protein expression is not substantially influenced by major ABCB1 genetic variants thus explaining in part results from case-control studies obtaining lack of association of ABCB1 polymorphisms to the risk of refractory epilepsy.
|
18494787 |
2008 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taking together, these data suggest that stimulation of EPO depending signaling system could not only play a central role in brain cell protection, but this system could be a new tool for reverse the pharmacoresistant phenotype in refractory epilepsy as well as in other pharmacoresistant hypoxic brain diseases expressing P-gp.
|
31379495 |
2019 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.
|
18812236 |
2009 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship between the MDR1 C3435T polymorphism and childhood refractory epilepsy needs further validation.
|
28284049 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both MDR1 gene expression and persistently low phenytoin levels likely share a common pathway liable to induce drug-resistant epilepsy.
|
10580886 |
1999 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have attempted to confirm the association between the ABCB1-C3435T polymorphism and drug-resistant epilepsy and produced discordant findings.
|
24794827 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The obtained results clearly confirm the lack of a connection between the occurrence of drug-resistant epilepsy and C435T polymorphism of the MDR1 gene irrespective of the definition of drug resistance applied to the patient.
|
25223475 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The efflux transporter P-glycoprotein encoded by the ATP-binding cassette (ABC)B1 gene may play a role in drug-resistant epilepsy by limiting gastrointestinal absorption and brain access of antiepileptic drugs (AEDs).
|
16753003 |
2006 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein (P-gp) has been implicated in the causation of refractory epilepsy.
|
15857428 |
2005 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The reported study was designed to explore associations between the MDR1-C3435T gene SNP and the risk of DRE in the Polish population.
|
27534401 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ABCC2 rs2273697 (1249G>A) and ABCB1 rs1045642 (3435C>T) polymorphisms were not associated with drug resistant epilepsy.
|
22630058 |
2012 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results revealed that LTG-loaded mPEG-PLA/TPGS mixed micelles enhanced the absorption of LTG at the nasal cavity and reduced the efflux of LTG in the brain, suggesting that the function of TPGS inhibited P-glycoprotein and LTG-loaded mPEG-PLA/TPGS mixed micelles had the potential to overcome refractory epilepsy.
|
29200847 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that ethnicity plays a role in the association between ABCB1 G2677T/A polymorphism and drug-resistant epilepsy.
|
26220385 |
2015 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The above three polymorphisms in the ABCB1 gene were not found to be significantly associated with drug resistant epilepsy in a western Chinese pediatric population.
|
21420937 |
2011 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescents.
|
23984379 |
2013 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship established in a subset of the Chinese population between the MDR1 C3435T polymorphism and refractory epilepsy will guide epilepsy treatment and development of new AEDs.
|
24953225 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TT genotype of ABCB1 rs717620 was also related with an increased risk of drug-resistant epilepsy (OR = 2.64, 95%CI = 1.03-7.13) compared to the CC+CT genotype in the recessive model.
|
27886333 |
2016 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No associations were found between the polymorphisms of the MDR1 gene and drug-resistant epilepsy.
|
20448249 |
2010 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of P-glycoprotein (P-gp) in the brain is an important mechanism involved in drug‑resistant epilepsy (DRE).
|
28627626 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Persistent low levels of AEDs in plasma and P-gp brain overexpression in several RE pediatric patients were reported.
|
17910594 |
2007 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results confirm earlier observations on absence of association of ABCB1 polymorphisms with medically refractory epilepsy.
|
19571437 |
2009 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggested that overexpression of P-gp and CYP3A during seizures and treated with CBZ may be regulated by PXR or NF-κB p65 activity and expression, which revealed a mechanism underlying the development of DRE.
|
30312753 |
2019 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Twenty-six patients (15 males, 11 females, age range 4-25 years, mean age 22.92 years, SD 11.19 years) with intractable epilepsy were included in this study; the clinical characteristics were considered, and the pathological changes as well as expression of MDR1 and GFAP in surgically removed brain tissues of each subject were examined under light and electron microscopy.
|
16998727 |
2006 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the expression levels of multidrug resistance gene 1 (MDR1), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance P-glycoprotein (P-gp) in peripheral blood of patients with refractory epilepsy.
|
29318116 |
2018 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1 expression is increased in brain of some patients with medically intractable epilepsy, suggesting that the patients' lack of response to medication may be caused by inadequate accumulation of AED in brain.
|
8001500 |
1995 |