Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, coexpression of Snail and ABCB1 was observed in CRC patients.
|
31774615 |
2020 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.
|
30741544 |
2019 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells.
|
31487863 |
2019 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.
|
30306567 |
2019 |
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, a panel of 5 SNPs, namely ABCC2 (-24C > T/rs717620 and c.4544 G > A/rs8187710), ABCG2 (c.421 C > A/rs2231142), ABCB1 (c.3435 C > T/rs1045642) and SLC31A1 (c.-36 + 2451 T > G/rs10981694), was evaluated to assess their association with grade 2-3 OXPN in metastatic CRC patients.
|
30713338 |
2019 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Further studies on herbal medicines with demonstrated effects against P-gp overexpression will aid in improving the efficacy of chemotherapy in CRC.
|
30158992 |
2018 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
While expression levels of Nrf2 and ABCB1 (P-gp) were markedly higher in both mRNA and protein levels in CRC biopsies (p < 0.01), Keap1 expression level was significantly lower in these samples (p < 0.05).
|
29793178 |
2018 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation.
|
30662808 |
2018 |
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer.
|
30213564 |
2018 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1.
|
30439718 |
2018 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, it is unclear whether similar mechanisms of doxorubicin resistance are involved in colorectal cancer (CRC).
|
29701752 |
2018 |
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the consequences of ABCB1/MDR1 loss-of-function in a common murine model for CAC (AOM/DSS).
|
28686677 |
2017 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, a significantly positive association between RARγ and MDR1 was demonstrated in CRC tissue microarrays.
|
28272990 |
2017 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1).
|
28667355 |
2017 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expressions of MDR-associated protein topoisomerase II (Topo II) and P-glycoprotein (P-gp) in CRC tissues were detected by immunohistochemistry.
|
28816939 |
2017 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.
|
28302530 |
2017 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
DTA0100 mitotic arrest properties were investigated in two multi-drug resistant cancer cell lines with P-glycoprotein overexpression (colorectal carcinoma and glioblastoma).
|
28502672 |
2017 |
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis.
|
29390571 |
2017 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The purpose of this present study was to investigate the reversal effect of BU on ABCB1-mediated multidrug resistance in colorectal cancer.
|
28624793 |
2017 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of cytochrome P450 2C19 (CYP2C19) and ATP-binding cassette, sub-family B member 1 (ABCB1) were significantly lower in the EREC group (6/15) compared to the NREC group (9/15) in colorectal cancer with metachronous liver metastasis and with serum CEA >5 ng/ml.
|
27127120 |
2016 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we showed that PIK3CA and PIK3CB are upregulated in CRCs and positively correlated with MDR-1, LRP, and GST-π.
|
26747178 |
2016 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that the Caudal-related homeobox transcription factor CDX2 transcriptionally regulates MDR1 expression in colorectal cancer.
|
27060927 |
2016 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the ABC transporters P-glycoprotein/multidrug resistance 1 and BRCP, in cooperation with IL-10, are involved in the biological mechanism underlying the protective effect of fiber intake in relation to CRC.
|
26109419 |
2015 |
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer.
|
25691056 |
2015 |
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Results revealed that the protein and messenger RNA expressions of Beclin1, LC3, mTOR, Raptor, Rictor, and MDR-1 in CRC are significantly higher than in adjacent tissues.
|
26363527 |
2015 |