|
Cholelithiasis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Methylation-specific PCR revealed statistical significant (P = 0.005) difference in methylation status of MASPIN promoter between gallstone and GBC patients.
|
30740890 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Survival analysis of TCGA data and clinical data suggested that TMC7, TMPRSS4, SCEL, SLC2A1, CENPF, SERPINB5 and SLC6A14 can be potential biomarkers for the prognosis of PC.
|
30639415 |
2019 |
|
Cholecystolithiasis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Methylation-specific PCR revealed statistical significant (P = 0.005) difference in methylation status of MASPIN promoter between gallstone and GBC patients.
|
30740890 |
2019 |
|
Rectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SERPINB5 Expression: Association with CCRT Response and Prognostic Value in Rectal Cancer.
|
29511373 |
2018 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In clinical samples, detection of unmethylated SERPINB5 was a specific marker for PDAC even in the context of pancreatitis and may provide the basis for a liquid biopsy option to detect PDAC.
|
26646275 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrated that the expression of SerpinB5 was downregulated in ESCC, and the positive SNPs might be associated with a risk of ESCC development.
|
25775950 |
2015 |
|
Squamous cell carcinoma of mouth
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to evaluate the loss of heterozygosity (LOH) in chromosomes 17p13 (p53 gene) and in 18q21 (mammary serine protease inhibitor [maspin] gene), and the expression of both genes in tissues, in patients with oral cavity squamous cell carcinoma (SCC).
|
24801268 |
2015 |
|
early pregnancy
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
The methylation status of the maspin promoter is an important factor that affects the migration and invasion of EVT cells during early pregnancy.
|
26263377 |
2015 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis and ELISAs revealed significant positive correlations between levels of serpin B5 and CEA in human colon cancer cell lines and in the blood of patients with CRC.
|
24114705 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serpin B5 is a CEA-interacting biomarker for colorectal cancer.
|
24114705 |
2014 |
|
Squamous cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, by combining the whole-genome DNA methylation pattern and the gene expression profile, we identified the six genes (CCDC37, CYTL1, CDO1, SLIT2, LMO3, and SERPINB5) that are regulated by DNA methylation, and we suggest their value as target molecules for further study of SCC.
|
22011669 |
2012 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mammary serine protease inhibitor B5 (SerpinB5) is a potential oncogene in gastric cancer (GC); however, the molecular mechanism by which SerpinB5 promotes oncogenesis remains elusive.
|
21725612 |
2011 |
|
Epithelial ovarian cancer
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Seven EOC cell lines and 110 advanced stage EOC specimens were analyzed for MASPIN promoter methylation.
|
21903246 |
2011 |
|
Benign Prostatic Hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
RARB, HIN1, BCL2, GSTP1, CCND2, EGFR5, APC, RASSF1A, MDR1, NKX2-5, CDH13, DPYS, PTGS2, EDNRB, MAL, PDLIM4, HLAa, ESR1 and TIG1 were highly methylated in PCa compared to BPH (p < 0.001), while SERPINB5, CDH1, TWIST1, DAPK1, THRB, MCAM, SLIT2, CDKN2a and SFN were not.
|
21694441 |
2011 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Seven EOC cell lines and 110 advanced stage EOC specimens were analyzed for MASPIN promoter methylation.
|
21903246 |
2011 |
|
Secondary malignant neoplasm of bone
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether maspin, when produced at endogenous levels, is capable of inhibiting metastasis to bone we transfected a bacterial artificial chromosome (BAC) genomic clone containing the maspin gene into PC-3 cells that aggressively metastasize to bone in an animal model.
|
18367129 |
2009 |
|
Squamous cell carcinoma of lip
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lip SCCs related to solar radiation show an intense presence of maspin protein in almost all tumor cells as well as the neighboring epithelium.
|
19222699 |
2009 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Most of them concluded that low or absent MASPIN cytoplasmic expression was more frequent in oral carcinomas with lymph node metastases.
|
18615330 |
2009 |
|
Anoxia
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Maspin modulates prostate cancer cell apoptotic and angiogenic response to hypoxia via targeting AKT.
|
18931702 |
2008 |
|
Complete trisomy 18 syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, the SERPINB5 gene on chromosome 18 was shown to exhibit different DNA-methylation patterns in the placenta and maternal blood cells, and the allelic ratio for placenta-derived hypomethylated SERPINB5 in maternal plasma was further shown to be useful for noninvasive detection of fetal trisomy 18.
|
18202156 |
2008 |
|
Trisomy 18 Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, the SERPINB5 gene on chromosome 18 was shown to exhibit different DNA-methylation patterns in the placenta and maternal blood cells, and the allelic ratio for placenta-derived hypomethylated SERPINB5 in maternal plasma was further shown to be useful for noninvasive detection of fetal trisomy 18.
|
18202156 |
2008 |
|
Endometrial Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Expression of maspin in endometrioid adenocarcinoma of endometrium.
|
17203179 |
2007 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates.
|
16633061 |
2006 |
|
Noninfiltrating Intraductal Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We conducted a study on 30 archival ductal carcinoma in situ (DCIS) specimens to determine if aberrant methylation of the maspin promoter occurred in vivo, and whether it occurred early in breast cancer evolution.
|
15256060 |
2005 |
|
Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant maspin expression by five pancreatico-biliary tract carcinoma cell lines was closely associated with demethylation at the maspin promoter.
|
15608662 |
2005 |