SERPINB5, serpin family B member 5, 5268

N. diseases: 87; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype BEFREE Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo. 23924927 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype BEFREE Apart from SERPINB2 and SERPINB5, the roles of the remaining 13 members of the human SERPINB family in cancer metastasis are still unknown. 21993616 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 AlteredExpression phenotype BEFREE Notably, there was 290-fold increase in SERPINB5, a tumor suppressor gene, and a 10-fold higher expression of KISS1, a metastasis suppressor gene, in the treated group. 21606571 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 AlteredExpression phenotype BEFREE Of the investigated metastasis suppressor genes, only higher AKAP12 mRNA expression was correlated with decreased metastasis (P < 0.05) and invasion scores (P < 0.01) while higher SERPINB5 mRNA expression was correlated with increased metastasis scores (P < 0.05). 20939879 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype BEFREE To investigate whether maspin, when produced at endogenous levels, is capable of inhibiting metastasis to bone we transfected a bacterial artificial chromosome (BAC) genomic clone containing the maspin gene into PC-3 cells that aggressively metastasize to bone in an animal model. 18367129 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype CTD_human Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures. 19514085 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype BEFREE Finally, engineered alterations in the expression of two of the epithelial genes (SERPINB5 and LTF) modified cell motility in vitro, in accordance with a possible causal role in metastasis. 17952122 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype BEFREE Expression of tumor suppressor gene, MASPIN, is associated with inhibition of tumor cell invasion and metastasis. 12006534 2002
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype BEFREE Thus, SERPINB5 can be used in gene therapy against breast tumor growth and metastasis. 12027560 2002
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.390 Biomarker phenotype BEFREE Transfection of MDA-MB-435 mammary carcinoma cells with the maspin gene did not alter the cells' growth properties in vitro, but reduced the cells' ability to induce tumors and metastasize in nude mice and to invade through a basement membrane matrix in vitro. 8290962 1994