PIGR, polymeric immunoglobulin receptor, 5284

N. diseases: 71; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.020 AlteredExpression disease BEFREE We hypothesize that differential regulation of PIGR mRNA stability may contribute to its downregulation in colon cancer. 14631119 2004
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.020 AlteredExpression disease BEFREE We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. pIgR expression is upregulated by IFN-gamma and IL-4 when HT-29 cells are grown in normal media, but this upregulation was significantly lower when cells were grown in vitamin A-depleted media. 9649586 1998