|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study suggested that the PTEN/PI3K/AKT signaling pathway plays an important role in thrombin/PAR1-mediated lung cancer cell growth and migration.
|
25861627 |
2015 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Methyl nonanoate, (R)-citronellol, cis-carveol (L-carveol), 3-methyl-Cyclohexanone, 4-carene and thujopsene were finally screened for PI3K targeted anti-cancer therapies which may find direct application as inhalers or sprays against lung cancer as these compounds are highly volatile.
|
28356026 |
2018 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The effect of paclitaxel combined with lobaplatin on the sensitivity of lung cancer cell line NCI-H446 through influencing the phosphatidylinositol 3-kinase (PI3K)/Akt pathway was investigated.
|
29616103 |
2018 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.
|
21688263 |
2012 |
|
Carcinoma of lung
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrated elevated levels of MARCKS and phospho-MARCKS in highly invasive lung cancer cell lines and lung cancer specimens from non-small-cell lung cancer patients. siRNA knockdown of MARCKS expression in these highly invasive lung cancer cell lines reduced cell migration and suppressed PI3K (phosphatidylinositol 3'-kinase)/Akt phosphorylation and Slug level.
|
23955080 |
2014 |
|
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we focused on Akt kinase-interacting protein1 (Aki1), a scaffold protein of PI3K (phosphoinositide 3-kinase)/PDK1 (3-phosphoinositide-dependent protein kinase)/Akt that determines receptor signal selectivity for non-mutated EGFR, and assessed its role in EGFR mutant lung cancer with or without gatekeeper T790M mutation.
|
23045273 |
2013 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cotransfection of the constitutively active mutant Rac-1 (Val12), an upstream activator of JNK, abrogated Deltap85-induced lung cancer cell death, whereas constitutively active mutant mitogen-activated protein kinase kinase (MKK)-1 (R4F) did not.
|
12714585 |
2003 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer.
|
19394761 |
2009 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibiting PI3K-AKt signaling pathway is involved in antitumor effects of ginsenoside Rg3 in lung cancer cell.
|
27930981 |
2017 |
|
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in PI3K/AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
|
26645682 |
2016 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The mechanism may involve of PI3K/AKT signaling pathways in A549 cells, which may a potential therapeutic target for the treatment of lung cancer.
|
30344755 |
2018 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggested that miR-26a is involved in the TLR9‑mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway.
|
24788552 |
2014 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our analysis also highlighted the potential of these LC-miRNAs to regulate the cell differentiation, proliferation, endocytosis and migration signaling logically required to cause an LC cell mainly through five canonical pathways (PI3K-Akt signaling pathway, pathways in cancer, MAPK signaling pathway, HTLV-I infection and focal adhesion).
|
24085243 |
2013 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, PI3K is a promising therapeutic target for lung cancer treatment.
|
29269744 |
2017 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
RAS signaling through PI3K is necessary for normal lymphatic vasculature development and for RAS-induced transformation in vitro and in vivo, especially in lung cancer, where it is essential for tumor initiation and necessary for tumor maintenance.
|
28847905 |
2018 |
|
Carcinoma of lung
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Treatment with cucurbitacin B also caused inhibition of PI3K/mTOR and signal transducer and activator of transcription (STAT)-3 signaling along with simultaneous activation of AMPKα levels in both EGFR-wild type and EGFR-mutant lung cancer cells.
|
27881463 |
2017 |
|
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PIK3CA mutations have been associated with poor prognosis in patients with colorectal or lung cancer.
|
23532889 |
2013 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways.
|
29115573 |
2018 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and self-renewal of lung cancer stem cells.
|
25738369 |
2015 |
|
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Activation to a large extent of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and mutations in the p53 gene are involved in lung cancer therapeutic resistance.
|
20811722 |
2010 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation.
|
27177359 |
2017 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway regulates a diverse set of cellular functions relevant to the growth and progression of lung cancer, including proliferation, survival, migration, and invasion.
|
28125432 |
2017 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Dual molecular targeted therapy for mTOR and PI3K may be a promising therapeutic strategy in the specific population of patients with lung cancer with LKB1 loss.
|
30825612 |
2019 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cells, they effectively associated with EGFR, promoted its ubiquitination and degradation, and as a result, blocked the downstream PI3K-Akt signal pathway.
|
25573345 |
2015 |
|
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Further investigations showed that the PI3K/Akt signalling pathway and COX-2 are involved in endothelial tube formation under the stimulation of lung cancer cells.
|
28173828 |
2017 |