|
Malignant neoplasm of stomach
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of stomach
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Based on these data, we initiated PIK3CA mutation screening in 94 human gastric cancers by direct sequencing of the gene regions in which 80% of all the known PIK3CA mutations were found.
|
15784156 |
2005 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
Strategies targeting PI3K signal transduction or the association of PI3K with Rb, or regulating PI3K-Rb interactions could be employed for gene therapy or chemotherapy of gastric cancer and other tumors.
|
15809724 |
2005 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
The cooperation between RUNX3 and the PI3K/Akt signaling pathway component FoxO3a/FKHRL1 suggests the putative role of RUNX3 in the homoeostasis of gastric cells and in stomach cancer control.
|
16627973 |
2006 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this review, we will discuss the involvement of E-cadherin, EGFR, ERBB2, MMR genes, KRAS, and PIK3CA in the development and progression of gastric cancer and their role as biomarkers or as novel putative targets for therapy.
|
19013893 |
2008 |
|
Malignant neoplasm of stomach
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that PrP(C)-induced MDR in gastric cancer is associated with activation of the PI3K/Akt pathway.
|
19143835 |
2009 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
The overall prevalence of PIK3CA mutations implies an important role for PIK3CA in gastric cancer.
|
20398348 |
2010 |
|
Malignant neoplasm of stomach
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling.
|
20954287 |
2010 |
|
Malignant neoplasm of stomach
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Other well-known oncogenic kinases (PI3K and RAF) are also activated in a small portion of gastric cancers.
|
21406037 |
2011 |
|
Malignant neoplasm of stomach
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
These results show that H. pylori infection induces AKT/PI3K-mediated phosphorylation of p27 at T157 and T198 to cause cytoplasmic p27 mislocalization in gastric cancer, and that p27 mislocalization is an adverse prognostic feature in gastric cancer.
|
21841827 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
siRNA mediated targeting of PIK3CA may specifically knockdown the expression of PIK3CA in gastric cancer cells, providing a potential implication for therapy of gastric cancer.
|
21990951 |
2011 |
|
Malignant neoplasm of stomach
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No relationship was found between PIK3CA mutations and clinicopathological characteristics and clinical outcome in gastric cancer.
|
22292935 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus far, the human epidermal growth factor receptor (HER) pathway, angiogenic pathway, and phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin pathway have emerged as potential avenues for targeted therapy in AGC patients.
|
22334453 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
CTD_human |
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.
|
22484628 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To define the inhibitory and pro-apoptotic effects of the two PI3K inhibitors BEZ235 and BKM120 in three human colon cancer (HT-29, HCT-116 and DLD-1) and three gastric cancer (NCI-n87, AGS and MKN-45), cell lines with different PIK3CA gene mutation status were used.
|
22543857 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of ZIC1 results in inactivation of Shh, PI(3)K and MAPK signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer.
|
22799764 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
PIK3R3, the gene that encodes the PI3K regulatory subunit p55γ, is over-expressed in glioblastoma and ovarian cancers, but its expression in gastric cancer (GC) is not known.
|
22876838 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
PI3K/AKT pathway may represent an important therapeutic target for gastric cancer.
|
23058013 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Integration of information on the genetic and epigenetic alterations revealed that the GCs with the CpG island methylator phenotype (CIMP) tended to have mutations of oncogenes, CTNNB1, ERBB2, KRAS, and PIK3CA.
|
23196062 |
2013 |
|
Malignant neoplasm of stomach
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
HER2 expression, PIK3CA mutations and EBV infection in gastric cancer were characterized. pAkt expression significantly correlates with HER2 expression and with a poor prognosis.
|
23236232 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
Notch2 may negatively regulate cell invasion by inhibiting the PI3K-Akt signaling pathway in gastric cancer.
|
23326131 |
2012 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
The present study was designed to test whether semaphorin 5A mediates the invasion and metastasis of gastric cancer via PI3K/Akt/uPA signaling.
|
23661031 |
2013 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggested that the PI3K/Akt inhibitor LY294002 can enhance chemosensitivity of human gastric cancer to VCR.
|
23743572 |
2013 |
|
Malignant neoplasm of stomach
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have investigated the frequency of molecular changes in the PI3K pathway in gastric cancer.
|
23813545 |
2013 |