|
Angiomatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soft tissue angiomatosis: another PIK3CA-related disorder.
|
31630434 |
2020 |
|
Otitis Media
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of the PI3K/AKT pathway and PTEN in otitis media.
|
31837294 |
2020 |
|
Vitamin D Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Vitamin D Deficiency Induces Insulin Resistance and Re-supplementation Attenuates Hepatic Glucose Output Via the PI3K-AKT-FOXO1 Mediated Pathway.
|
31797544 |
2020 |
|
Somatotropin deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA.
|
31729162 |
2020 |
|
Epiretinal Membrane
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, we show that p110δ, a catalytic subunit of receptor-regulated PI3K isoform δ, is highly expressed in epiretinal membranes from patients with PVR, and that idelalisib, a specific inhibitor of PI3Kδ, effectively inhibits vitreous-induced Akt activation, proliferation, migration and contraction of retinal pigment epithelial cells derived from an epiretinal membrane of a PVR patient.
|
31786159 |
2020 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistic studies revealed that STK33 promoted growth and progression of PNET via activation of the PI3K/AKT/mTOR pathway.
|
31261148 |
2020 |
|
Lipomatosis of Nerve
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, the PIK3CA mutation status of histologically confirmed lipomatosis of nerve, including cases involving proximal nerves, and cases without territory overgrowth, has not been determined.
|
31481664 |
2020 |
|
Cerebral hypoperfusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, CIG treatment improved learning and memory deficit induced by chronic cerebral hypoperfusion via increasing neurotrophic factors thus protecting glutamate receptors and activating PI3K/Akt/GSK3β/CREB signaling pathway in rats.
|
31669346 |
2020 |
|
Infectious Otitis Media
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of the PI3K/AKT pathway and PTEN in otitis media.
|
31837294 |
2020 |
|
Isolated somatotropin deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA.
|
31729162 |
2020 |
|
Peripheral neuropathy due to and following chemotherapy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The HMGB-1-TLR4-PI3K/Akt-MMP-9 axis is involved in the crosstalk between macrophages and neurons in the pathological process of CIPN in mice.
|
31465111 |
2020 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PI3K/Akt activity is up-regulated within mesocorticolimbic structures in animal models of alcoholism, but less is known regarding PI3K/Akt activity in animal models of cocaine addiction.
|
30450839 |
2019 |
|
Arteriosclerosis Obliterans
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-126 promotes endothelial cell apoptosis by targeting PI3K/Akt in rats with lower limb arteriosclerosis obliterans.
|
31389593 |
2019 |
|
Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The key novel insights gained from the present study are: i) KCa2.3 was upregulated in patients with atrial fibrillation (AF) and in patients with AF combined with mitral value disease; ii) LSS induced a profound upregulation of KCa2.3 mRNA and protein expression in H9c2 cells; iii) PI3K activation was associated with LSS‑induced upregulation of the KCa2.3 channel; iv) PI3K activation was mediated by PI3K/Akt‑dependent Akt activation; and v) LSS induction of KCa2.3 involved the binding of p300 to transcription factors in the promoter region of the KCa2.3 gene.
|
30664154 |
2019 |
|
Melanoma, B16
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overall, the inhibitory effect of GBEE on the growth of B16 melanoma transplant tumor in mice is related to inhibiting angiogenesis, and the mechanism involves the regulation of PI3K/Akt/ HIF-lα/VEGF signaling pathway.
|
31531063 |
2019 |
|
Bone Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, our data demonstrated that garcinol inhibited the RANKL-induced osteoclastogenesis by suppressing the MAPK, NF-κB, and PI3K-AKT signaling pathways and thus has potential as a novel therapeutic option for osteolytic bone diseases.
|
30471112 |
2019 |
|
Metabolic Bone Disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We concluded that ebselen could attenuate osteogenic dysfunction of BMSCs induced by H<sub>2</sub>O<sub>2</sub> through an antioxidant effect and the activation of the PI3K/Akt pathway, suggesting that ebselen has a potential therapeutic effect for patients with metabolic bone diseases.
|
31345368 |
2019 |
|
Malignant neoplasm of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy.
|
31370278 |
2019 |
|
Intracranial Aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms.
|
30101479 |
2019 |
|
Brain Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of the PI3K‑mTOR autophagy pathway in nerve damage in rats with intermittent hypoxia‑aggravated whole brain ischemia.
|
31173224 |
2019 |
|
Transient Ischemic Attack
|
0.010 |
Biomarker
|
disease |
BEFREE |
N-Linoleyltyrosine Protects against Transient Cerebral Ischemia in Gerbil via CB2 Receptor Involvement in PI3K/Akt Signaling Pathway.
|
31484847 |
2019 |
|
Cholesteatoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ratios of LC3-II/I and Beclin-1 expression on WB were significantly higher in cholesteatoma epithelium compared with EAC epithelium or COM epithelium, and there was a significantly higher ratio of p-PI3K/PI3K and p-AKT/AKT in cholesteatoma epithelium compared with EAC epithelium.
|
31663994 |
2019 |
|
Contracture of joint
|
0.010 |
Biomarker
|
disease |
BEFREE |
Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule.
|
31511778 |
2019 |
|
Craniosynostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The most common diagnoses were syndromic craniosynostosis in 8/35 children (22.9%), among which sevenare FGFR-related and one ERF-related craniosynostosis; disorders of the RAS/MAPK pathway, termed RASopathies or RAS/MAPK syndromes in 9/35 (25.7%); disorders of the PTEN-PI3K/AKT signal transduction cascade, termed PTENopathies in 3/35 children (8.6%); and chromosomal rearrangements in 6/35 patients (17.1%), two of whom with del16p11.2.
|
31363831 |
2019 |
|
Diphtheria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
DTaP5-HB-IPV-Hib is a fully liquid, hexavalent vaccine containing a 5-antigen pertussis component, approved since 2016 in Europe [Vaxelis; DTaP5-HB-IPV-Hib vaccine: Diphtheria, tetanus, pertussis (5 acellular components: pertussis toxoid [PT], filamentous haemagglutinin [FHA], pertactin (PRN), and fimbriae Types 2 and 3 [FIM]), hepatitis B (recombinant DNA: rDNA), poliomyelitis (inactivated) and Haemophilus influenzae type b conjugate vaccine (adsorbed); MCM Vaccine B.V., The Netherlands] for primary and booster vaccination in infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive diseases caused by Haemophilus influenzae type b.
|
30882742 |
2019 |