|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A panel of inhibitors of PI3K and Akt treated osteosarcoma cells and blocked kinase activity.
|
28289332 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A panel of inhibitors of PI3K and Akt treated osteosarcoma cells and blocked kinase activity.
|
29213214 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results of the present study indicated that CLDN12 promoted cell proliferation and migration through the PI3K/Akt signaling pathway in osteosarcoma cells, suggesting that CLDN12 may be a potential agent in the treatment of patients with osteosarcoma.
|
31807064 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells through down-regulation of the MDR1 and the PI3K/Akt pathway, and has the potential to be an adjunct to chemotherapy for osteosarcoma.
|
25747987 |
2015 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis revealed that lnPTENP1 transfection regulated osteosarcoma cell growth via the PI3K/AKT signaling pathway.
|
29805503 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIX1 promoted the progression of osteosarcoma via regulating PTEN/PI3K/AKT signaling cascade, which might provide a new potent therapeutic target for osteosarcoma.
|
29807230 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.
|
30182951 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although IP6 exposures had modest to minimal effects on cell proliferation, we observed reduced cellular glycolysis, down-regulation of PI3K/Akt signaling and suppression of OS metastatic progression.
|
28404949 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Valosin-containing protein (VCP) promotes the development of metastasis in osteosarcoma (OS) via the PI3K/Akt signaling pathway.
|
31516594 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, our data demonstrated that downregulation of HOXB7 inhibited proliferation, invasion, and tumorigenesis, partly through suppressing the PI3K/Akt signaling pathway in osteosarcoma cells.
|
27983923 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigated the role of miR-155 in regulating osteosarcoma cell autophagy, chemosensitivity to Adriamycin (ADM), and PTEN-PI3K/AKT/mTOR signaling pathway.
|
29412697 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We discovered that TIIA inhibited osteosarcoma cell survival through class I PI3K and Akt signaling pathways.
|
30258193 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, whether the malignant phenotype of osteosarcoma (OS) cells is regulated by the PI3K/Akt/FASN signaling pathway and how the PI3K family specific inhibitor, 2‑(4‑morpholinyl)‑8‑phenyl‑chromone (LY294002) affects the malignant phenotype of OS cells remains to be elucidated.
|
25351625 |
2015 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that TGF-α/EGFR interaction elicits PI3K and Akt activation, which in turn activates NF-κB, resulting in the expression of ICAM-1 and contributing the migration of human osteosarcoma cells.
|
24685520 |
2014 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ISL could retard proliferation and promote apoptosis of U2OS cells possibly by suppressing the PI3K/Akt signalling pathway, indicating that it might be a potential therapeutic agent for osteosarcoma treatment.
|
29936511 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma.
|
23372675 |
2013 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Western blot analysis was performed to detect the expression levels of phosphatidylinositol 3‑kinase (PI3K), phospho (p)‑PI3K, RAC‑alpha serine/threonine‑protein kinase (AKT), p‑AKT and NF‑κB inhibitor α (IκBα) in osteosarcoma cells transfected with H19 siRNA.
|
29568924 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We proposed that VRK1 and H2A<sup>T120ph</sup> could be the potential targets for osteosarcoma diagnosis and treatment.HighlightsH2A<sup>T120ph</sup> is specifically promoted by Ras-PI3K pathway activation.H2A<sup>T120ph</sup> joins in the oncogenic effects of Ras-PI3K pathway on osteosarcoma.H2A<sup>T120ph</sup> regulates the transcription of Ras-PI3K-targeted genes.VRK1 takes part in the regulatory function of Ras-PI3K pathway on H2A<sup>T120ph</sup>.
|
31810390 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fangchinoline suppresses the proliferation, invasion and tumorigenesis of human osteosarcoma cells through the inhibition of PI3K and downstream signaling pathways.
|
28586029 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The activation of PI3K/Akt and the overexpression of fatty acid synthase (FASN) are frequently observed in human osteosarcoma (OS).
|
24366211 |
2014 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the FASN/HER2/PI3K/Akt signaling pathway may be a potential therapeutic target for OS management.
|
28565856 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells.
|
31000382 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRCA1-Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K/Akt Pathway.
|
28256910 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, XBP1 is up-regulated and has a pro-tumor effect in OS with activation of PI3K/mTOR signaling.
|
26633383 |
2015 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma.
|
30014744 |
2018 |