|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of the expression of these PI3K genes can predict aggressive disease, and indicates stage-dependent involvement of PI3K-pathway members in neuroblastoma.
|
23232578 |
2013 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PI3K inhibitor PI103 cooperates with TRAIL to synergistically induce apoptosis (combination index < 0.1), to suppress clonogenic survival, and to reduce tumor growth in a neuroblastoma in vivo model.
|
21355080 |
2011 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results show that the ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma.
|
20811723 |
2010 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The way of PI3K/AKT/mTOR pathway activation in neuroblastoma (NB) is not well established.
|
21225506 |
2010 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that repression of Survivin by FKHRL1 facilitates FKHRL1-induced apoptosis and sensitizes to cell death induced by DNA-damaging agents, which supports the central role of PI3K-PKB-FKHRL1 signaling in drug resistance of human NB.
|
19211844 |
2009 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we investigated the phosphorylation status of key proteins in the PI3K/AKT/mTOR pathway and the effects of the mTOR inhibitors rapamycin and CCI-779 on neuroblastoma tumorigenesis.
|
18026138 |
2008 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological inhibition of PI3K greatly reduced the ability of PDGF-BB to block gp120 IIIB-mediated apoptosis and cell death in human neuroblastoma cells.
|
18973553 |
2008 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting MYCN, as a novel effector of PI3K-mediated angiogenesis, has significant potential for the treatment of highly vascularized, malignant NB.
|
18278068 |
2008 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both MAPK and PI3K pathways were involved in BDNF protection of NB cells from paclitaxel-induced cell death, while PI3K predominantly mediated BDNF protection of NB cells from etoposide or cisplatin-induced cell death.
|
16778834 |
2007 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of the PI3K/Akt pathway does not increase the sensitivity of neuroblastoma cell lines to TRAIL-induced apoptosis.
|
16769337 |
2006 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent with these observations, PI3K inhibition in MYCN-amplified human neuroblastoma cell lines resulted in decreased levels of Mycn protein without affecting levels of MYCN mRNA and caused decreased proliferation and increased apoptosis.
|
16912192 |
2006 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesize that VEGF will up-regulate survivin, a member of the IAP family of anti-apoptotic proteins, via the PI3K/Akt cell signaling pathway in human neuroblastoma cells.
|
15882878 |
2005 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to determine whether the phosphatidylinositol 3-kinase (PI3K)/Akt pathway can alter the expression of survivin and facilitate tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in neuroblastoma cells.
|
15065019 |
2004 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of PI3K/AKT survival pathway may contribute to the increased drug resistance in TrkB-expressing neuroblastomas.
|
12438236 |
2002 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show that the glial cell line-derived neurotrophic factor (GDNF) activates the PI3K/Akt-signaling pathway in human neuroblastoma cells that express functional Ret-receptor complexes.
|
12485836 |
2002 |