Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 Biomarker disease BEFREE PIK3CD encodes the phosphoinositide 3-kinase (PI3K) catalytic subunit, p110δ, a lipid kinase linked to neurodevelopmental disorders, including schizophrenia (SZ). 31211828 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 GeneticVariation disease BEFREE The intronic single-nucleotide polymorphism rs707284 in ERBB4 links to PI3K-AKT suppression in SZ. 28384043 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 Biomarker disease BEFREE The PIK3CD gene encodes the delta catalytic subunit of phosphoinositide 3-kinase (PI3K), an element of the neuregulin 1-downstream ErbB4-PI3K signaling pathway, which was recently identified as a molecular target for the treatment of schizophrenia. 26960157 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 Biomarker disease BEFREE Moreover, the study further highlights the potential of targeting the PI3K pathway for the treatment of schizophrenia. 27122041 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 Biomarker disease BEFREE The phosphoinositide 3'-kinase (PI3K)--protein kinase B (AKT1)--glycogen synthase kinase (GSK)-3β system is modulated by several factors implicated in the pathophysiology of schizophrenia. 22209534 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 Biomarker disease BEFREE It is thought that reduced activity of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway could at least partially explain the cognitive impairment, synaptic morphologic abnormality, neuronal atrophy and dysfunction of neurotransmitter signaling in schizophrenia. 22771711 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 GeneticVariation disease BEFREE Here we identify a genetically regulated, pharmacologically targetable, risk pathway associated with schizophrenia and with ErbB4 genetic variation involving increased expression of a PI3K-linked ErbB4 receptor (CYT-1) and the phosphoinositide 3-kinase subunit, p110δ (PIK3CD). 22689948 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.370 Biomarker disease CTD_human Increased exonic de novo mutation rate in individuals with schizophrenia. 21743468 2011