Developmental Disabilities
|
0.010 |
Biomarker
|
group |
BEFREE |
Mutations in the p85α regulatory subunit encoded by PIK3R1 can both activate PI3K through oncogenic truncations in the iSH2 domain, or inhibit PI3K through developmental disorder mutations in the cSH2 domain.
|
31831213 |
2020 |
Otitis Media
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of the PI3K/AKT pathway and PTEN in otitis media.
|
31837294 |
2020 |
Vitamin D Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Vitamin D Deficiency Induces Insulin Resistance and Re-supplementation Attenuates Hepatic Glucose Output Via the PI3K-AKT-FOXO1 Mediated Pathway.
|
31797544 |
2020 |
Epiretinal Membrane
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, we show that p110δ, a catalytic subunit of receptor-regulated PI3K isoform δ, is highly expressed in epiretinal membranes from patients with PVR, and that idelalisib, a specific inhibitor of PI3Kδ, effectively inhibits vitreous-induced Akt activation, proliferation, migration and contraction of retinal pigment epithelial cells derived from an epiretinal membrane of a PVR patient.
|
31786159 |
2020 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistic studies revealed that STK33 promoted growth and progression of PNET via activation of the PI3K/AKT/mTOR pathway.
|
31261148 |
2020 |
Cerebral hypoperfusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, CIG treatment improved learning and memory deficit induced by chronic cerebral hypoperfusion via increasing neurotrophic factors thus protecting glutamate receptors and activating PI3K/Akt/GSK3β/CREB signaling pathway in rats.
|
31669346 |
2020 |
Megalencephaly cutis marmorata telangiectatica congenita
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Megalencephaly-capillary malformation syndrome (MCAP) is a brain overgrowth disorder characterized by cortical malformations (specifically polymicrogyria), vascular anomalies, and segmental overgrowth secondary to somatic activating mutations in the PI3K-AKT-MTOR pathway (PIK3CA).
|
31729162 |
2020 |
Infectious Otitis Media
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of the PI3K/AKT pathway and PTEN in otitis media.
|
31837294 |
2020 |
Peripheral neuropathy due to and following chemotherapy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The HMGB-1-TLR4-PI3K/Akt-MMP-9 axis is involved in the crosstalk between macrophages and neurons in the pathological process of CIPN in mice.
|
31465111 |
2020 |
Alcoholic Intoxication, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PI3K/Akt activity is up-regulated within mesocorticolimbic structures in animal models of alcoholism, but less is known regarding PI3K/Akt activity in animal models of cocaine addiction.
|
30450839 |
2019 |
Arteriosclerosis Obliterans
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-126 promotes endothelial cell apoptosis by targeting PI3K/Akt in rats with lower limb arteriosclerosis obliterans.
|
31389593 |
2019 |
Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The key novel insights gained from the present study are: i) KCa2.3 was upregulated in patients with atrial fibrillation (AF) and in patients with AF combined with mitral value disease; ii) LSS induced a profound upregulation of KCa2.3 mRNA and protein expression in H9c2 cells; iii) PI3K activation was associated with LSS‑induced upregulation of the KCa2.3 channel; iv) PI3K activation was mediated by PI3K/Akt‑dependent Akt activation; and v) LSS induction of KCa2.3 involved the binding of p300 to transcription factors in the promoter region of the KCa2.3 gene.
|
30664154 |
2019 |
Melanoma, B16
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overall, the inhibitory effect of GBEE on the growth of B16 melanoma transplant tumor in mice is related to inhibiting angiogenesis, and the mechanism involves the regulation of PI3K/Akt/ HIF-lα/VEGF signaling pathway.
|
31531063 |
2019 |
Bone Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, our data demonstrated that garcinol inhibited the RANKL-induced osteoclastogenesis by suppressing the MAPK, NF-κB, and PI3K-AKT signaling pathways and thus has potential as a novel therapeutic option for osteolytic bone diseases.
|
30471112 |
2019 |
Metabolic Bone Disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We concluded that ebselen could attenuate osteogenic dysfunction of BMSCs induced by H<sub>2</sub>O<sub>2</sub> through an antioxidant effect and the activation of the PI3K/Akt pathway, suggesting that ebselen has a potential therapeutic effect for patients with metabolic bone diseases.
|
31345368 |
2019 |
Bronchiolitis Obliterans
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although B cells rely on PI3Kδ pathway signaling and GC formation is disrupted resulting in a substantial decrease in Ig production, PI3Kδ kinase-dead mutant donor bone marrow-derived GC B cells still supported BO cGVHD generation.
|
30748099 |
2019 |
Malignant neoplasm of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy.
|
31370278 |
2019 |
Intracranial Aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms.
|
30101479 |
2019 |
Brain Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of the PI3K‑mTOR autophagy pathway in nerve damage in rats with intermittent hypoxia‑aggravated whole brain ischemia.
|
31173224 |
2019 |
Transient Ischemic Attack
|
0.010 |
Biomarker
|
disease |
BEFREE |
N-Linoleyltyrosine Protects against Transient Cerebral Ischemia in Gerbil via CB2 Receptor Involvement in PI3K/Akt Signaling Pathway.
|
31484847 |
2019 |
Cholesteatoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ratios of LC3-II/I and Beclin-1 expression on WB were significantly higher in cholesteatoma epithelium compared with EAC epithelium or COM epithelium, and there was a significantly higher ratio of p-PI3K/PI3K and p-AKT/AKT in cholesteatoma epithelium compared with EAC epithelium.
|
31663994 |
2019 |
Contracture of joint
|
0.010 |
Biomarker
|
disease |
BEFREE |
Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule.
|
31511778 |
2019 |
Craniosynostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The most common diagnoses were syndromic craniosynostosis in 8/35 children (22.9%), among which sevenare FGFR-related and one ERF-related craniosynostosis; disorders of the RAS/MAPK pathway, termed RASopathies or RAS/MAPK syndromes in 9/35 (25.7%); disorders of the PTEN-PI3K/AKT signal transduction cascade, termed PTENopathies in 3/35 children (8.6%); and chromosomal rearrangements in 6/35 patients (17.1%), two of whom with del16p11.2.
|
31363831 |
2019 |
Adenoid Cystic Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
JQ1 and PI3K inhibition synergistically reduce salivary adenoid cystic carcinoma malignancy by targeting the c-Myc and EGFR signaling pathways.
|
30269363 |
2019 |
Encephalitis, St. Louis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SLE may be a novel phenotype of GOF mutation in PI3CKD gene (GOF PIK3CD).
|
31045771 |
2019 |