|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
A selective PI3K-δ inhibitor IC87114 and an ER-folding chaperone chemical 4-PBA were applied to the Aspergillus fumigatus (Af)-induced asthma mouse model.
|
31713846 |
2020 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we described the role of miRNA-133a in asthma and demonstrated it in regulating airway remodeling of asthma through the phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway by targeting IGF-1 receptor (IGF1R).
|
30146725 |
2019 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Azithromycin influences airway remodeling in asthma via the PI3K/Akt/MTOR/HIF-1α/VEGF pathway.
|
30334401 |
2019 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this review, we specifically summarize the recent advancement of our knowledge on the critical roles of PI3K-δ in the pathogenesis of bronchial asthma.
|
31323822 |
2019 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Phosphoinositide-3-kinase-δ (PI3Kδ) is a key regulator in the process of IgE mediated mast cell degranulation, which directly induces allergic diseases, such as asthma.
|
30528237 |
2019 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Secreted Hsp90α medicates HDM-induced asthmatic airway epithelial barrier dysfunction via PI3K/AKT pathway, indicating that anti-secreted Hsp90α therapy might be a potential treatment to asthma in future.
|
31747880 |
2019 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The PI3K-AKT pathway is known to regulate cytokines in dust mite-induced pediatric asthma.
|
30406061 |
2018 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
This work describes the discovery and optimization of inhaled PI3Kδ inhibitors intended for the treatment of severe asthma and COPD.
|
30351000 |
2018 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Therefore, local delivery of a pan-PI3K inhibitor prodrug reduces systemic on-target side effects but effectively treats asthma and irreversible pulmonary fibrosis.
|
30542075 |
2018 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we revealed that OX40L could regulate differentiation of helper T cells via PI3K/AKT and p38 MAPK signaling pathway in asthma.
|
29554934 |
2018 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
When Brg1 was knocked out, the asthma severity was ameliorated and the PI3K/Akt/mTOR pathway was activated.
|
30149919 |
2018 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
After further cluster and enrichment analysis of the protein-protein interaction network of MXGSD bioactive component targets and asthma-related targets, we found that the neurotrophin signaling pathway, estrogen signaling pathway, PI3K-Akt signaling pathway, and ErbB signaling pathway might serve as the key points and principal pathways of MXGSD gene therapy for asthma from a systemic and holistic perspective, and also provides a novel idea for the development of new drugs for asthma.
|
30478434 |
2018 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The PI3Kδ inhibitor IC87114 is a potential therapeutic agent against neutrophil-dominant asthma.
|
29504610 |
2018 |
|
Asthma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that cigarette smoke can reduce the expression of HDAC2 in asthma and the process was achieved by activating the PI3K-δ/Akt signaling pathway.
|
28960099 |
2018 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Investigation into the Role of PI3K and JAK3 Kinase Inhibitors in Murine Models of Asthma.
|
28293189 |
2017 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The PI3K pan-inhibitor LY294002 attenuated not only IL-25-induced asthma-like AHR and airway inflammation but also remodelling in this model, suggesting that PI3K is a major downstream messenger for IL-25 and that targeting this pathway might reduce asthma symptoms in the short term and airway remodelling in the longer term.
|
27556731 |
2017 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The phosphoinositide 3-kinase (PI3K) and Notch signaling pathways are associated with T cell signaling, proliferation, and differentiation, and are important in the progression of asthma.
|
28746467 |
2017 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma.
|
25918132 |
2015 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our study is the first to demonstrate that the PI3K-NFAT3 pathway is positively involved in IL-13-induced mucus production, and provided novel insights into the molecular mechanism of asthma mucus hypersecretion.
|
24583134 |
2014 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Activation of intracellular mitogen-activated protein kinase (MAPK)/nuclear factor-kappa B (NF-κB) and their related signal pathways including protein kinase C (PKC), phosphoinositide 3-kinase (PI3K) and protein kinase A (PKA) signaling pathways may result in airway kinin receptor upregulation, which is suggested to play an important role in the development of AHR.
|
23428345 |
2013 |
|
Asthma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This study compared the expression of PI3K isoforms by ASM cells from donors with asthma (A), chronic obstructive pulmonary disease (COPD), or neither disease (NA), and investigated the role of PI3K isoforms in the production of TGFβ1 induced pro-inflammatory cytokine and contractile proteins in ASM cells.
|
22015454 |
2012 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
M2 biomarkers were first identified by using MDMs exposed to T(H)2 cytokines and then used to phenotype sputum and bronchoalveolar lavage (BAL) macrophages from 12 healthy control subjects, 12 patients with mild asthma, and 14 patients with moderate asthma and to assess the effects of corticosteroids and phosphatidylinositol 3-kinase (PI3K) inhibitors.
|
22981793 |
2012 |