Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in RGS4, G72/G30, and PIP5K2A were neither associated with SZ-ND nor with SZ-D. SNP8NRG241930 showed association with the PANSS cognitive and hostility/excitability factors, rs1011313 with the negative factor and SDS total score, and rs10917670 in RGS4 was associated with the depression factor.
|
19937977 |
2010 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population.
|
16823801 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia.
|
16801950 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The results of this study suggest that any contribution of previously implicated DNA variants within the PIP5K2A gene to schizophrenia susceptibility in the Indonesian population is only minor.
|
18314871 |
2008 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in RGS4, G72/G30, and PIP5K2A were neither associated with SZ-ND nor with SZ-D. SNP8NRG241930 showed association with the PANSS cognitive and hostility/excitability factors, rs1011313 with the negative factor and SDS total score, and rs10917670 in RGS4 was associated with the depression factor.
|
19937977 |
2010 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that any contribution of previously implicated DNA variants within the PIP5K2A gene to schizophrenia susceptibility in the Indonesian population is only minor.
|
18314871 |
2008 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We find that wild-type PIP5K2A but not the schizophrenia-associated mutant (N251S)-PIP5K2A activates heteromeric KCNQ2/KCNQ3 and KCNQ3/KCNQ5, the molecular correlate of neuronal M channels.
|
18545987 |
2008 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.
|
25025909 |
2014 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Coexpression of the schizophrenia-associated mutant (N251S)PIP5K2A significantly decreased I(glu) in oocytes expressing EAAT3 with or without additional expression of wild type PIP5K2A.
|
19644675 |
2009 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both schizophrenia and bipolar disorder.
|
17410640 |
2007 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Coexpression of the schizophrenia-associated mutant (N251S)PIP5K2A significantly decreased I(glu) in oocytes expressing EAAT3 with or without additional expression of wild type PIP5K2A.
|
19644675 |
2009 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite this apparent paradox, our data may therefore suggest involvement of PIP4K2A in schizophrenia in those families for whom genetic variation in DTNBP1 appears also to be a risk factor.
|
19475563 |
2010 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia.
|
25548108 |
2014 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The results of this study suggest that any contribution of previously implicated DNA variants within the PIP5K2A gene to schizophrenia susceptibility in the Indonesian population is only minor.
|
18314871 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results confirm that the PIP5K2A gene merits further study as a susceptible gene for schizophrenia.
|
17555944 |
2007 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Screening of PIP5K2A promoter region for mutations in bipolar disorder and schizophrenia.
|
16094259 |
2005 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our results confirm that the PIP5K2A gene merits further study as a susceptible gene for schizophrenia.
|
17555944 |
2007 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both schizophrenia and bipolar disorder.
|
17410640 |
2007 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Despite this apparent paradox, our data may therefore suggest involvement of PIP4K2A in schizophrenia in those families for whom genetic variation in DTNBP1 appears also to be a risk factor.
|
19475563 |
2010 |