|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population.
|
16823801 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia.
|
16801950 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The results of this study suggest that any contribution of previously implicated DNA variants within the PIP5K2A gene to schizophrenia susceptibility in the Indonesian population is only minor.
|
18314871 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in RGS4, G72/G30, and PIP5K2A were neither associated with SZ-ND nor with SZ-D. SNP8NRG241930 showed association with the PANSS cognitive and hostility/excitability factors, rs1011313 with the negative factor and SDS total score, and rs10917670 in RGS4 was associated with the depression factor.
|
19937977 |
2010 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that any contribution of previously implicated DNA variants within the PIP5K2A gene to schizophrenia susceptibility in the Indonesian population is only minor.
|
18314871 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We find that wild-type PIP5K2A but not the schizophrenia-associated mutant (N251S)-PIP5K2A activates heteromeric KCNQ2/KCNQ3 and KCNQ3/KCNQ5, the molecular correlate of neuronal M channels.
|
18545987 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.
|
25025909 |
2014 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Coexpression of the schizophrenia-associated mutant (N251S)PIP5K2A significantly decreased I(glu) in oocytes expressing EAAT3 with or without additional expression of wild type PIP5K2A.
|
19644675 |
2009 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both schizophrenia and bipolar disorder.
|
17410640 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Screening of PIP5K2A promoter region for mutations in bipolar disorder and schizophrenia.
|
16094259 |
2005 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our results confirm that the PIP5K2A gene merits further study as a susceptible gene for schizophrenia.
|
17555944 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both schizophrenia and bipolar disorder.
|
17410640 |
2007 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both schizophrenia and bipolar disorder.
|
17410640 |
2007 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Screening of PIP5K2A promoter region for mutations in bipolar disorder and schizophrenia.
|
16094259 |
2005 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population.
|
16823801 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
|
23512250 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.
|
29348612 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility.
|
27149463 |
2016 |
|
Breast Carcinoma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
|
23996088 |
2013 |
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
|
29632299 |
2018 |
|
Influenza due to Influenza A virus subtype H1N1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.
|
26379185 |
2015 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we systematically investigated the relationship between SNPs at PIP4K2A locus and ALL susceptibility, and further found potential causal variant candidates, thus better elucidating the role of PIP4K2A gene in leukemogenesis.
|
27149463 |
2016 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A MIGICCL Study.
|
28476190 |
2016 |