|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
BEFREE |
Polycystic kidney disease 2 (which encodes TRPP2) knockout mice displayed decreased cerebrovascular SOCE-induced contraction.
|
31541223 |
2019 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
CTD_human |
The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
|
30883612 |
2019 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
BEFREE |
We generated the first inducible, smooth muscle-specific knockout mice for a TRP channel, namely for PKD2 (TRPP1), to investigate arterial myocyte and blood pressure regulation by this protein.
|
30511640 |
2018 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
|
29899465 |
2018 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
BEFREE |
ADPKD is caused by mutations in the gene encoding either polycystic kidney disease 1 ( PKD1) or polycystic kidney disease 2 ( PKD2).
|
29475398 |
2018 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutational screening of PKD2 gene in the north Indian polycystic kidney disease patients revealed 28 genetic variations.
|
29321346 |
2017 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
CTD_human |
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.
|
28887310 |
2017 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant.
|
27071085 |
2016 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
The polycystin complex mediates Wnt/Ca(2+) signalling.
|
27214281 |
2016 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
CTD_human |
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
|
25877301 |
2015 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
MGD |
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
|
25574838 |
2015 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
CTD_human |
N-glycosylation determines the abundance of the transient receptor potential channel TRPP2.
|
24719335 |
2014 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
BEFREE |
Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2).
|
23390131 |
2013 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Type of PKD1 mutation influences renal outcome in ADPKD.
|
23431072 |
2013 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Neonatal onset autosomal dominant polycystic kidney disease (ADPKD) in a patient homozygous for a PKD2 missense mutation due to uniparental disomy.
|
22114106 |
2012 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD).
|
21115670 |
2011 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
MGD |
Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease.
|
20093497 |
2010 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Perinatal deaths in a family with autosomal dominant polycystic kidney disease and a PKD2 mutation.
|
18635443 |
2008 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
MGD |
Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.
|
16301212 |
2006 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns.
|
15772804 |
2005 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
CTD_human |
Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells.
|
15001556 |
2004 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
PKD2 mutations in a Czech population with autosomal dominant polycystic kidney disease.
|
14993477 |
2004 |
|
Polycystic kidney disease, type 2
|
0.970 |
Biomarker
|
disease |
MGD |
Two populations of node monocilia initiate left-right asymmetry in the mouse.
|
12859898 |
2003 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease.
|
12707387 |
2003 |
|
Polycystic kidney disease, type 2
|
0.970 |
GeneticVariation
|
disease |
UNIPROT |
Four novel mutations of the PKD2 gene in Czech families with autosomal dominant polycystic kidney disease.
|
11968093 |
2002 |