|
Colorectal Carcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Neuropsychological Tests
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Common genetic variation and performance on standardized cognitive tests.
|
20125193 |
2010 |
|
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In agreement with the above data, haploinsufficiency of a different Prep1-deficient (null) allele accelerates EmuMyc lymphoma growth.
|
20106730 |
2010 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In agreement with the above data, haploinsufficiency of a different Prep1-deficient (null) allele accelerates EmuMyc lymphoma growth.
|
20106730 |
2010 |
|
Childhood Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In agreement with the above data, haploinsufficiency of a different Prep1-deficient (null) allele accelerates EmuMyc lymphoma growth.
|
20106730 |
2010 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The synthesis of middle-to-late-replicating DNA can be affected independently of the rest of the genome by down-regulating the tumor suppressor PREP1 (PKNOX1).
|
29453404 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Previously we have shown that Prep1 is a haploinsufficient tumor suppressor that inhibits neoplastic transformation by competing with myeloid ecotropic integration site 1 for binding to the common heterodimeric partner Pbx1.
|
25157139 |
2014 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Prep1 is essential for embryogenesis, but in the adult it also acts as a tumor suppressor.
|
30604851 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
All these findings suggest that disruption of the Prep1/p160 molecular interaction enhances insulin sensitivity impaired by ceramides in skeletal muscle cells and indicate this complex as an important target for type 2 diabetes.
|
29069751 |
2017 |
|
Down Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results provide a rationale for the involvement of PREP1 in the apoptotic phenotype of DS tissues and indicate that differences in Prep1 level can have drastic effects.
|
20110257 |
2010 |
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Pre-B-cell leukemia homeobox (Pbx)-regulating protein-1 (Prep1) is a ubiquitous homeoprotein involved in early development, genomic stability, insulin sensitivity, and hematopoiesis.
|
25157139 |
2014 |
|
Metabolic Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In this review we have underlined how important metabolic functions are controlled by TALE proteins, in particular by Prep1, leading to hypothesis that its suppression might represent beneficial effect in the care of metabolic diseases.
|
30002646 |
2018 |
|
Metabolic Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
These data implicate the upregulated hepatic expression of Pknox1 in T2DM complicated with NAFLD may be caused by the reduced expression of miR-17 family, indicating that developing miRNA-mediated regulation strategies on Pknox1 may provide new therapeutic options for metabolic disease.
|
30338914 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Pre-B-cell leukemia transcription factor (PBX)/three-amino-acid loop extension (TALE) class transcription factors [PBX1-4, Meis homeobox (Meis) 1-3, pbx/knotted 1 homeobox (Prep) 1, 2] are involved in tumorigenesis and metastasis.
|
21703237 |
2011 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These findings point to a novel role of the PREP1 homeoprotein in the control of the TGF-β pathway, EMT, and metastasis in NSCLC.
|
25157139 |
2014 |
|
Teratocarcinoma
|
0.020 |
Biomarker
|
disease |
LHGDN |
F9 teratocarcinoma cells stably transfected with PREP-1 had an increased DNA binding activity to a PREP-PBX-responsive element.
|
12871956 |
2003 |
|
Teratocarcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
By using fibroblasts from DS patients and by overexpressing Prep1 in F9 teratocarcinoma and Prep1(i/i) MEF to single out the role of the protein, we report that excess Prep1 increases the sensitivity of cells to genotoxic stress and the extent of the apoptosis directly correlates with the level of Prep1.
|
20110257 |
2010 |
|
Complete Trisomy 21 Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results provide a rationale for the involvement of PREP1 in the apoptotic phenotype of DS tissues and indicate that differences in Prep1 level can have drastic effects.
|
20110257 |
2010 |
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Cytogenetic analysis shows the presence of numerous chromosomal aberrations and aneuploidy in very early-passage Prep1(i/i) MEFs.
|
21715654 |
2011 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
|
18644868 |
2008 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
|
18644868 |
2008 |
|
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
|
18644868 |
2008 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we establish the competitive relationship between PKNOX1 and MEIS1 in PBX-containing complex formation and determine the antagonistic role of PKNOX1 to leukemia in a murine MLL-AF9 model.
|
27123834 |
2016 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We report here: (i) overexpression of PKNOX1 in DS fetal brains; (ii) in vitro specific binding of PKNOX1 to the Pbx/POU site of the FABP7 promoter; (iii) in vivo FABP7 promoter trans-activation in cultured neuroblastoma cells caused by PKNOX1 overexpression.
|
12771203 |
2003 |
|
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Progression of retinitis pigmentosa on multimodal imaging: The PREP-1 study.
|
30552737 |
2019 |