PLAU, plasminogen activator, urokinase, 5328

N. diseases: 439; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 AlteredExpression disease BEFREE The expression of uPA and especially the over-expression of PAI-1 seem to correlate to the progression of local inflammatory response in acute appendicitis. 19153874 2009
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.300 Biomarker disease CTD_human Endogenous proteolytic activity in a rat model of spontaneous cerebral stroke. 12742636 2003
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia
0.300 Biomarker disease CTD_human
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.210 Therapeutic disease RGD Inhaled unfractionated heparin improves abnormalities of alveolar coagulation, fibrinolysis and inflammation in endotoxemia-induced lung injury rats. 23324284 2013
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.210 GeneticVariation disease LHGDN Association between urokinase haplotypes and outcome from infection-associated acute lung injury. 17994220 2008
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.210 Biomarker disease RGD [Effect of inhalation of aerosolized unfractioned heparin on peri alveolar coagulability and inflammatory response in endotoxin induced acute lung injury rat model]. 21473829 2011
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.020 Biomarker disease BEFREE This study established that uPA gene therapy effectively induces functionally significant angiogenesis in models of acute MI and hind limb ischemia. 17653104 2007
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.020 Biomarker disease BEFREE Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction. 30889909 2019
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE We examined mRNA expression of the urokinase-type plasminogen activator (uPA), its receptor (uPAR), and the plasminogen activator inhibitor 1 (PAI-1) in a panel of adenocarcinomas of the pancreas (PC) and cancers of the papilla of Vater (CPV). 18376309 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group BEFREE In this study, we analyzed the role of the uPAR/uPA system in both the development and progression of pancreatic cancer in invasive ductal adenocarcinomas of the pancreas (PDA) and their premalignant precursors (PanIN lesions) in 50 patients with long-term clinical follow-up. 19435784 2009
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group LHGDN Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. 18376307 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group BEFREE Using in situ hybridization to analyze the coexpression of laminin-5 and components of the plasminogen activation system, we found that the histological distribution of laminin-5-positive budding cancer cells at the invasion front in colon adenocarcinomas was identical to that of the receptor for urokinase-type plasminogen activator. 7664291 1995
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group LHGDN We have studied the expression of urokinase-type plasminogen activator (uPA) mRNA, uPA receptor (uPAR) mRNA and immunoreactivity, and type-1 plasminogen activator inhibitor (PAI-1) mRNA and immunoreactivity in 16 prostate adenocarcinomas and 9 benign prostate hyperplasias. uPA mRNA and uPAR mRNA expression were found in 9 and 8 of the adenocarcinomas, respectively, and in 7 and 6 of the benign hyperplasias, respectively. 15515049 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400 1999
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE The inhibitory effects of amiloride on uPA gene expression reported in this paper may offer the prospect of developing new therapeutic approaches to the prevention of invasion and metastasis by adenocarcinomas. 7750207 1995
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. 1850957 1991
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE We have studied the expression of urokinase-type plasminogen activator (uPA) mRNA, uPA receptor (uPAR) mRNA and immunoreactivity, and type-1 plasminogen activator inhibitor (PAI-1) mRNA and immunoreactivity in 16 prostate adenocarcinomas and 9 benign prostate hyperplasias. uPA mRNA and uPAR mRNA expression were found in 9 and 8 of the adenocarcinomas, respectively, and in 7 and 6 of the benign hyperplasias, respectively. 15515049 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group BEFREE Finally, expression of miR-193a is inversely correlated with PLAU and K-Ras in human colon adenocarcinomas. 21670079 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE The expressions of uPA and p38MAPK proteins were significantly higher in esophageal squamous cell carcinoma or adenocarcinoma than in normal esophageal mucosa tissue (both <i>P</i><0.0001). 30568465 2018
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon
0.010 Biomarker disease BEFREE We first showed that active site-inhibited u-PA could displace endogenous u-PA from the surface of the human colon adenocarcinoma cell line HCT 116. 1648983 1991
CUI: C0281361
Disease: Adenocarcinoma of pancreas
Adenocarcinoma of pancreas
0.020 AlteredExpression disease BEFREE Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400 1999
CUI: C0281361
Disease: Adenocarcinoma of pancreas
Adenocarcinoma of pancreas
0.020 Biomarker disease BEFREE The median and range of the ratios of uPA mRNA measures between tumor tissue and non-involved pancreatic tissue was 17.1 (1.4-653.6) for pancreatic adenocarcinoma (P < 0.001), 3.9 (0.7-7.7) for ampullary carcinoma (P = 0.055) and 1.9 (0.6-5.9) for mucinous cystadenoma tissue (P = 0.052). uPA low tumors were associated with an exuberant stromal reaction, whereas uPA high tumors showed little stromal response. 15683429 2005
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell
0.300 Biomarker disease CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400 1999
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic
0.300 Biomarker disease CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400 1999
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular
0.300 Biomarker disease CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400 1999