PLAU, plasminogen activator, urokinase, 5328

N. diseases: 439; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. 21896743 2011
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. 18819934 2008
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE A correlation between overexpression of urokinase-type plasminogen activator receptor (uPAR) and glioblastoma invasion has also been established. 17273768 2007
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE A bispecific immunotoxin (IT) called DTAT13 was synthesized in order to target simultaneously the urokinase-type plasminogen activator receptor (uPAR)-expressing tumor neovasculature and IL-13 receptor expressing glioblastoma cells with the goal of intratumoral administration for brain tumors. 15047912 2004
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE Stably transfecting human glioblastoma cells with antisense uPA decreased the amount of cell-bound uPA and disrupted actin cytoskeleton formation and cell migration. 12545160 2003
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE We assessed how expression of an amino-terminal fragment (ATF) of uPA that contains binding site to uPAR affects the invasiveness of SNB19 human glioblastoma cells. 12420219 2002
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE To investigate the role of uPA in the invasive process of brain tumors, we stably transfected a human glioblastoma cell line SNB19 with a vector capable of expressing an antisense transcript complementary to the 1020 bases at the 3' end of the uPA cDNA. 11489835 2001
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE We further studied the activation and inhibition of uPA promoter by co-expression of a transactivation domain lacking c-jun: a dominant negative ERK1 and ERK2 mutant and a dominant negative c-raf in glioblastoma cell line showed repressed uPA promoter activity compared with the effect of the empty expression vector. 11115541 2001
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE Downregulation of urokinase-type plasminogen activator receptor (uPAR) induces caspase-mediated cell death in human glioblastoma cells. 11688967 2000
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE To explore whether downregulation of uPAR inhibits tumor formation and invasiveness, a human glioblastoma cell line was transfected with a cDNA construct corresponding to 300 bp of the human uPAR's 5' end in an antisense orientation, resulting in a reduced number of uPA receptors. 9219733 1997
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE Furthermore, adherent human U-251MG glioblastoma cells in vitro expressed u-PAR and u-PA proteins, which localized to sites of integrin alpha nu beta 3 cell-matrix contacts. 7747809 1995
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE Immunocytochemical staining for uPA showed strong immunoreactivity in the tumor cells and vasculature of glioblastomas and anaplastic astrocytomas but undetectable or very low immunoreactivity for uPA in low-grade gliomas and normal brain tissues. uPA mRNA was located in astrocytoma and endothelial cells and was heterogeneously distributed within glioblastoma, with preferential localization near vascular proliferation and at the leading edge of the tumor. uPA expression was dramatically higher in highly malignant astrocytomas, especially glioblastomas, and was correlated with malignant progression of astrocytomas. 8033079 1994