|
Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Finally, the SADDAN-FGFR3 double mutant unable to bind PLCγ1 failed to promote paxillin hyperphosphorylation, pointing to PLCγ1 as an early player in mediating paxillin alterations.
|
29242050 |
2018 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML.
|
28978037 |
2017 |
|
Addictive Behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Conversely, overexpression of PLCγ1 both reduces the motivation for cocaine and reverses dendritic spine density, suggesting a potential target for the treatment of addiction in chronic users.
|
28808012 |
2017 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
PLCγ1 was highly expressed in humangastric adenocarcinomas, especially in the region with lymph node metastasis.
|
25308733 |
2014 |
|
Adult Angiosarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recurrent PTPRB and PLCG1 mutations in angiosarcoma.
|
24633157 |
2014 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.310 |
Biomarker
|
disease |
BEFREE |
Subsequently, 13 hub genes including CFLAR, GCNT2, IFNG, IL17A, IL22, MIP, PLCG1, PTH, PTPN6, REG1A, SNAP25, SUPT7L, and TP63 were shown to be related to cutaneous T-cell lymphoma (CTCL) and adult T-cell lymphoma/leukemia (ATLL).In summary, in addition to the reported genes (IL17F, PLCG1, IFNG, and PTH) in CTCL/ATLL, the other high instable genes may serve as novel biomarkers for the regulation of the biological processes and molecular mechanisms of CTLT (MF/SS).
|
29794791 |
2018 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Integrated molecular analysis of adult T cell leukemia/lymphoma.
|
26437031 |
2015 |
|
Angioimmunoblastic Lymphadenopathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Moreover, half of the patients carried virtually mutually exclusive mutations in other TCR-related genes, most frequently in PLCG1 (14.1%), CD28 (9.4%, exclusively in AITL), PI3K elements (7%), CTNNB1 (6%), and GTF2I (6%).
|
27369867 |
2016 |
|
Angioimmunoblastic Lymphadenopathy
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Antibodies specific to phosphorylated ZAP70, ITK and PLCγ1 were used to identify the activation status of intracellular proteins involved in TCR signaling in AITL patients.
|
30814910 |
2019 |
|
Angiosarcoma of liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.
|
26474454 |
2015 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LAT-PLC-γ1 interaction may contribute to LAT activity in vivo and LAT protects against asthma partly via Raf-MEK-ERK and PI3K-AKT-CREB pathways.
|
28063403 |
2017 |
|
Atrial Fibrillation
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism.
|
11409699 |
2001 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism.
|
11409699 |
2001 |
|
Birth Weight
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
|
31043758 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Borderline Personality Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have identified several hub genes (CAMK2A, HSP90AA1 and PLCG1) among those risk genes, and observed significant enrichment of the BPD risk genes in certain pathways such as calcium signaling, oxytocin signaling and circadian entrainment.
|
31150948 |
2019 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer.
|
20514023 |
2010 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
PLCγ1 overexpression is a strong predictive surrogate marker of development of metastases in early Luminal-A and -B breast cancer patients, being able to discriminate patients with high and low risk of metastases.
|
31362705 |
2019 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this review, the role of PLC-γ1 in breast cancer and its clinical implications will be discussed, as well as its potential as a prognostic factor and a therapeutic target.
|
28829192 |
2017 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show that down-regulation of PLCgamma1 expression severely impairs activation of the small GTP-binding protein Rac and cell invasion in breast cancer cell lines and U87 in vitro.
|
19074886 |
2008 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Thus, targeting PLCγ1 pathways might represent a potential therapeutic approach for the prevention of metastatic disease in breast cancer.
|
22847294 |
2013 |
|
Bronchopulmonary Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have identified several hub genes (CAMK2A, HSP90AA1 and PLCG1) among those risk genes, and observed significant enrichment of the BPD risk genes in certain pathways such as calcium signaling, oxytocin signaling and circadian entrainment.
|
31150948 |
2019 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
PLCγ1 is a central signal transducer of growth factor and cytokine signaling pathways that are involved in tumorigenesis.
|
21840932 |
2011 |