PLCG1, phospholipase C gamma 1, 5335

N. diseases: 116; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.160 Biomarker group BEFREE The enzyme phospholipase C gamma 1 (PLCγ1) has been identified as a potential drug target of interest for various pathological conditions such as immune disorders, systemic lupus erythematosus, and cancers. 31548507 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.160 Biomarker group BEFREE Phospholipase Cγ1 links inflammation and tumorigenesis in colitis-associated cancer. 29464031 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.160 GeneticVariation group BEFREE Furthermore, in tandem SH2 and γSA constructs, molecular dynamics and NMR results show that the Arg687Trp mutant in PLCγ1 (equivalent to the cancer mutation Arg665Trp in PLCγ2) perturbs the dynamic allosteric pathway. 29972810 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.160 Biomarker group BEFREE Taken together, our data suggest that (i) UCP2 is an important regulator of mitochondrial redox status and lipid signaling; (ii) hydrogen peroxide might mediate UCP2's tumor promoting activity; and (iii) pharmacological disruption of PLCγ-1 and/or hydrogen peroxide may have clinical utility for UCP2 overexpressed cancers. 28574619 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.160 GeneticVariation group GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.160 Biomarker group BEFREE PLCγ1 activities play an important role in the metastasis of gastric adenocarcinoma, and may serve as a potential therapeutic target in this type of cancer. 25308733 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.160 Biomarker group BEFREE We further show that this novel PDK1-PLCγ1 pathway is important for cancer cell invasion. 22454520 2012