TPCN1, two pore segment channel 1, 53373

N. diseases: 26; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 Biomarker disease BEFREE Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line. 29448931 2018
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 Biomarker disease BEFREE The role of miR-222 in PTC cell migration ability was assessed with Transwell<sup>®</sup> assays and wound-healing assays in both TPC-1 and K1 cells. 29882471 2018
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 Biomarker disease BEFREE NEAT1_2 expression was markedly increased in PTC tissues and the PTC cell lines (K1 and TPC1). 29515109 2018
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 Biomarker disease BEFREE Matrine is a traditional Chinese medicine and has been demonstrated as a promising alternative drug for the treatment of TPC-1 human PTC. 30127885 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE TPC-1 and SW1736 thyroid carcinoma cells were used. 30396956 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE Matrine inhibits TPC-1 human thyroid cancer cells via the miR-21/PTEN/Akt pathway. 30127885 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE SW1736 and TPC-1 human thyroid carcinoma cells were used. 29285650 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE Our purpose was to study the combined effect of HDAC inhibitors (HDACi) and ionizing irradiation in thyroid cancer cell lines (Nthy-ori 3-1, WRO, TPC-1 and 8505c). 30125607 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 AlteredExpression disease BEFREE The expression of YAP1 significantly increased in the thyroid carcinoma cell line compared with normal thyroid cells, among which the expression of YAP1 in TPC-1 was the highest. 29762852 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.100 Biomarker disease BEFREE Thus, the biological role of LRP4 in the thyroid cancer in the present study was investigated using the PTC cell lines TPC1, BCPAP and KTC-1. 29885843 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE Rg3 apparently inhibited the migration and invasion in four papillary thyroid cancer (PTC) cells (TPC-1, BCPAP, C643, and Ocut-2c cells) and pulmonary metastasis in lung metastasis model of C643 cells in nude mice. 30136914 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE Knockdown of Tuft1 in TPC-1 and SW579 cells suppressed the invasion and proliferation of TC cells and increased the apoptosis of TC cells. 30662679 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion. 30251060 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE Cellular studies with TPC-1 and BCPAP cells demonstrated that USP33 can attenuate the cell capacities of proliferation, migration and invasion. 29533940 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE SiRNA experiments with a PTC cell line, TPC1, showed inhibition of proliferation with siRNAs for all three lncRNAs while invasion was inhibited with siRNAs for ROR and HOTAIR. 29280051 2018
CUI: C0007115
Disease: Malignant neoplasm of thyroid
Malignant neoplasm of thyroid
0.100 Biomarker disease BEFREE In this study, we evaluated the activities of hydroxytyrosol against papillary (TPC-1, FB-2) and follicular (WRO) thyroid cancer cell lines. 27592355 2017
CUI: C0007115
Disease: Malignant neoplasm of thyroid
Malignant neoplasm of thyroid
0.100 Biomarker disease BEFREE In addition, a knockdown of galectin-1 in papillary (TPC-1) and anaplastic (8505C) thyroid cancer cell lines was achieved by lentiviral transduction for in vitro experiments. 28677745 2017
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.100 Biomarker disease BEFREE In this study, we evaluated the activities of hydroxytyrosol against papillary (TPC-1, FB-2) and follicular (WRO) thyroid cancer cell lines. 27592355 2017
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.100 Biomarker disease BEFREE In addition, a knockdown of galectin-1 in papillary (TPC-1) and anaplastic (8505C) thyroid cancer cell lines was achieved by lentiviral transduction for in vitro experiments. 28677745 2017
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.100 AlteredExpression disease BEFREE Induction of epithelial to mesenchymal transition (EMT) by transforming growth factor (TGF)-beta in a PTC cell line (TPC1) led to increased MALAT1 expression, supporting a role for MALAT1 in EMT in thyroid tumors. 27696303 2017
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 Biomarker disease BEFREE The functions of the ZCCHC12 gene in PTC cell lines (TPC1 and BCPAP) transfected with small interfering RNA were determined through cell colony formation assay, migration assay, and invasion assay. 28424903 2017
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 GeneticVariation disease BEFREE In conclusion, the results of the present study suggested that LAPTM4B*2 was a susceptibility factor for PTC in the female Chinese population and this may not be caused by the transcriptional regulation of LAPTM4B polymorphism region in TPC1 and B-CPAP cell lines. 28927096 2017
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 GeneticVariation disease BEFREE MATERIAL AND METHODS Four cell lines included TPC-1 (BRAFWT/WT), BCPAP (BRAFV600E/V600E), PCCL3, and PTC3-5 (RET/PTC), were grown in culture in vitro with or without suppression of NF-κB using pyrrolidine dithiocarbamate (PDTC), and cell proliferation, and cell migration were evaluated. 29117154 2017
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 Biomarker disease BEFREE In the present study, CD44<sup>+</sup>/CD24<sup>-</sup> cells were isolated from the TPC-1 PTC cell line and biological function assays revealed that CD44<sup>+</sup>/CD24<sup>-</sup> cells were significantly more proliferative and chemoresistant compared with CD44<sup>-</sup>/CD24<sup>-</sup> cells. 29201169 2017
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.100 Biomarker disease BEFREE Induction of epithelial to mesenchymal transition (EMT) by transforming growth factor (TGF)-beta in a PTC cell line (TPC1) led to increased MALAT1 expression, supporting a role for MALAT1 in EMT in thyroid tumors. 27696303 2017