PLG, plasminogen, 5340

N. diseases: 586; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3850141
Disease: Acute-On-Chronic Liver Failure
Acute-On-Chronic Liver Failure 		0.010 Biomarker disease BEFREE Increased Serum Soluble Urokinase Plasminogen Activator Receptor Predicts Short-Term Outcome in Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure. 31191644 2019
CUI: C4699511
Disease: Stroke of undetermined etiology
Stroke of undetermined etiology 		0.010 Biomarker disease BEFREE Notably, F2 and PLG were identified as the critical proteins for large artery atherosclerosis (LAA), lacunar, cardioembolic, stroke of other determined etiology (SOE) and stroke of undetermined etiology (SUE). 31561071 2019
CUI: C4699512
Disease: Large-artery atherosclerosis (embolus/thrombosis)
Large-artery atherosclerosis (embolus/thrombosis) 		0.010 Biomarker disease BEFREE Notably, F2 and PLG were identified as the critical proteins for large artery atherosclerosis (LAA), lacunar, cardioembolic, stroke of other determined etiology (SOE) and stroke of undetermined etiology (SUE). 31561071 2019
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis 		0.010 Biomarker disease BEFREE Recombinant plasminogen activator (reteplase) is a third generation thrombolytic agent which has been used on coronary artery thrombosis and acute myocardial infarction. 30568707 2018
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.010 AlteredExpression disease BEFREE Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis. 29691836 2018
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.010 Biomarker disease BEFREE Urine albumin is a superior predictor of preeclampsia compared to urine plasminogen in type I diabetes patients. 29305116 2018
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.010 Biomarker disease BEFREE In this review, we describe mechanisms of proteolytic enzymes (MMP-9 and plasminogen activation system), their role in Down syndrome, their inhibition by EGCG, possible degradation of this polyphenol and the ability of EGCG and its degradation products to cross the blood-brain barrier. 29342922 2018
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.010 AlteredExpression disease BEFREE Gelatin zymography revealed that plasminogen supplementation significantly promoted activation of the elastolytic enzyme MMP-2 in rat DA ECs. 29304073 2018
CUI: C0013595
Disease: Eczema
Eczema 		0.010 AlteredExpression disease BEFREE Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis. 29691836 2018
CUI: C0015923
Disease: Fetal Alcohol Syndrome
Fetal Alcohol Syndrome 		0.010 AlteredExpression disease BEFREE In conclusion, astrocyte PA system may play a major role in the modulation of neuronal plasticity; ethanol-induced upregulation of tPA levels and plasmin activity may be responsible for altered neuronal plasticity in FASD. 29885422 2018
CUI: C0019101
Disease: Hemorrhagic Fever with Renal Syndrome
Hemorrhagic Fever with Renal Syndrome 		0.010 Biomarker disease BEFREE We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). 29450213 2018
CUI: C0020295
Disease: Hydronephrosis
Hydronephrosis 		0.010 Biomarker disease BEFREE Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidney. 29767556 2018
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.010 Biomarker disease BEFREE Integrin α<sub>V</sub>β<sub>3</sub> can regulate plasminogen activation on THP-1 monocytes and to a lesser extent on HUVECs. 29852400 2018
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.010 Biomarker disease BEFREE A low level of tissue-type plasminogen activator (gene name PLAT) is considered a cause of stromal tissue edema because of insufficient plasmin activation in NP; however, the mechanism regulating PLAT gene expression levels is still unclear. 29962211 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.010 Biomarker phenotype BEFREE Interleukin (IL)‑6, transcription factor AP‑1 (c‑Jun) and urikinase‑type plasminogen activator (Plau) were identified as hub proteins and key genes in neuropathic pain. 29532897 2018
CUI: C0031069
Disease: Familial Mediterranean Fever
Familial Mediterranean Fever 		0.010 AlteredExpression disease BEFREE The FMF with periodontitis and amyloidosis with periodontitis groups had higher salivary PLG levels compared with those in the CP group. 29520774 2018
CUI: C0032059
Disease: Placentitis (disorder)
Placentitis (disorder) 		0.010 GeneticVariation phenotype BEFREE A total of 18 proteins were up-regulated in amniotic fluid during placentitis, including haptoglobin, plasminogen isoform X2 and plasminogen-like isoform X1 which were found exclusively in samples from mares with placentitis. 29626984 2018
CUI: C0043046
Disease: Wasting Syndrome
Wasting Syndrome 		0.010 GeneticVariation disease BEFREE Mice with single and combined deficiencies of FVIII (F8<sup>-/-</sup>) and plasminogen (Plg<sup>-/-</sup>) were evaluated for phenotypic characteristics of plasminogen deficiency, including wasting disease, shortened lifespan, rectal prolapse, and multiorgan fibrin deposition. 30459211 2018
CUI: C0085083
Disease: Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome 		0.010 Biomarker disease BEFREE The pre-ovulatory FF level of suPAR was significantly lower in women developing severe OHSS, indicating that the plasminogen activator system could be involved in the pathophysiology of OHSS. 30232642 2018
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.010 Biomarker disease BEFREE A second confirmatory phase on an independent cohort of 131 PDAC patients, 30 chronic pancreatitis patients, and 131 healthy subjects confirmed the PDAC association for MMP7, CCN2, IGFBP2, TSP2, sICAM1, TIMP1, and PLG Multivariable logistic regression model identified biomarker panels discriminating respectively PDAC versus healthy subjects (MMP7 + CA19.9, AUC = 0.99, 99% CI = 0.98-1.00) (CCN2 + CA19.9, AUC = 0.96, 99% CI = 0.92-0.99) and PDAC versus chronic pancreatitis (CCN2 + PLG+FN+Col4 + CA19.9, AUC = 0.94, 99% CI = 0.88-0.99). 29941541 2018
CUI: C0221014
Disease: Reactive systemic amyloidosis
Reactive systemic amyloidosis 		0.010 Biomarker disease BEFREE There are no published studies regarding the role of the plasminogen (PLG) system in familial Mediterranean fever (FMF), FMF-associated secondary amyloidosis, or chronic periodontitis (CP), although recent limited data have focused on the association between FMF and chronic periodontitis. 29520774 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.010 Biomarker disease BEFREE Urokinase plasminogen activator and beta-2 microglobulin were positively and matrix metalloproteinase-9 was negatively associated with the severity of hepatic fibrosis. 28548299 2018
CUI: C0264550
Disease: Pleural effusion associated with pulmonary infection
Pleural effusion associated with pulmonary infection 		0.010 Biomarker disease BEFREE Parapneumonic effusion (PPE) is commonly caused by Gram-positive bacteria (GPB) and often presents with pleural loculation, which is characterized by overproduction of plasminogen activator inhibitor (PAI)-1. 28836366 2018
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.010 AlteredExpression disease BEFREE The FMF with periodontitis and amyloidosis with periodontitis groups had higher salivary PLG levels compared with those in the CP group. 29520774 2018
CUI: C0279646
Disease: Childhood Acute Monocytic Leukemia
Childhood Acute Monocytic Leukemia 		0.010 Biomarker disease BEFREE Integrin α<sub>V</sub>β<sub>3</sub> can regulate plasminogen activation on THP-1 monocytes and to a lesser extent on HUVECs. 29852400 2018