PLG, plasminogen, 5340

N. diseases: 586; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease BEFREE Plasminogen activator inhibitor type-1 (PAI-1) is a <u>ser</u>ine <u>p</u>rotease <u>in</u>hibitor (serpin) implicated in numerous pathological processes, including coronary heart disease, arterial and venous thrombosis, and chronic fibrotic diseases. 30510136 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 AlteredExpression disease BEFREE Compared with the control group, the CAD group displayed significantly higher serum levels of retinol-binding protein-4 (RBP4), pentraxin 3 (PTX3), galectin-3 (GAL-3), and plasminogen activator inhibitor (PAI-1), and significantly lower levels of netrin-1 (NTN1), interleukin-37 (IL-37), and adiponectin (ADP) (all P < 0.05). 31464731 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease BEFREE In 106 stable CAD subjects undergoing intravascular ultrasound with virtual histology (IVUS-VH), we measured D-dimer, lipoprotein(a) (Lp(a)), plasminogen, biomarkers reflecting oxidation-specific epitopes (OSE) such as oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB), OxPL on plasminogen (OxPL-PLG), and autoantibodies to phosphorylcholine-BSA [PC-BSA] and a malondialdehyde [MDA] mimotope. 29344841 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease BEFREE Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients. 29109596 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease BEFREE Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease. 28550093 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease BEFREE The study further provides evidence that in addition to PLG, the currently known shared susceptibility loci of CAD and periodontitis, ANRIL and CAMTA1/VAMP3, are subjected to transforming growth factor-β regulation. 25466412 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease GWASCAT A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. 26343387 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease BEFREE Soluble urokinase plasminogen activator receptor: a risk factor for carotid plaque, stroke, and coronary artery disease. 24253546 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease GWASDB Large-scale association analysis identifies new risk loci for coronary artery disease. 23202125 2013
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease LHGDN Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. 19074676 2009
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease BEFREE Coronary artery disease (CAD) is less common in African than Indian or White subjects and elevated plasminogen activator inhibitor (PAI)-1 levels may be a risk factor for CAD. 17467713 2008
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease BEFREE To get a better insight into the role of hemostasis in coronary artery disease (CAD), we assessed the impact of von Willebrand factor (vWF), fibrinogen, thrombin-antithrombin (TAT) complexes, D-dimers, and plasmin-antiplasmin (PAP) complexes on the risk of cardiovascular event in a prospective cohort of CAD patients. 17023678 2006
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease BEFREE The objective of our study is to evaluate the single locus and combined effects of three different genetic polymorphisms (methylenetetrahydrofolate reductase C677T polymorphism, plasminogen activator inhibitor 4G/5G polymorphism, and endothelial nitric oxide synthase 3-27 base pairs repeat polymorphism) on the presence and extent of coronary artery disease in patients with early-onset coronary artery disease. 16845248 2006
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease BEFREE Levels of fibrinogen, factor VII (FVII), factor XIII (FXIII), plasminogen activator inhibitor (PAI)-1, and tissue plasminogen activator have been associated with coronary artery disease as have genetic polymorphisms. 11884298 2002
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 Biomarker disease BEFREE Increased circulating levels of type 1 plasminogen activator inhibitor (PAI-1) have been associated with coronary artery disease (CAD). 10235431 1999
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease BEFREE Disturbances in fibrinolytic activity, such as increase in plasminogen activator inhibitor (PAI) activity, have been linked with an increased risk for coronary artery disease (CAD) and myocardial infarction (MI). 10494775 1999
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.200 GeneticVariation disease BEFREE In a logistic regression model, including age, BMI, cholesterol, sex, smoking, triglycerides, and plasminogen activator inhibitor antigen as covariates, genotype and fibrinogen levels were significantly associated with CAD. 8908392 1996