|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) isozymes comprise a novel tumor suppressor family whose two members, PHLPP1 and PHLPP2, are deleted as frequently as PTEN in cancers such as those of the prostate.
|
24392697 |
2014 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.
|
28008906 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.
|
28008906 |
2016 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) has been known to exert tumor suppressive activity for long without much knowledge about its regulation and implications.
|
29626488 |
2018 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell motility.
|
29930380 |
2018 |
|
Chronic granulomatous disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
A male CGD patient with pg91(phox) deficiency exhibited a trend toward prolongation of this calcium response, whereas two other CGD patients (one with p47 and one with 67(phox) deficiencies) had normal calcium transients.
|
15527168 |
2004 |
|
Aarskog syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the pleckstrin homology (PH) domain of the FGD1 gene in an Italian family with faciogenital dysplasia (Aarskog-Scott syndrome).
|
10930571 |
2000 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
|
17611497 |
2007 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
|
17611497 |
2007 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
melanoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Absence of mutations in the pleckstrin homology (PH) domain of protein kinase B (PKB/Akt) in malignant melanoma.
|
11828257 |
2002 |
|
Endometrial Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.
|
19853286 |
2010 |
|
Carcinoma, Transitional Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma.
|
19389506 |
2009 |
|
Urothelial Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma.
|
19389506 |
2009 |
|
Paroxysmal kinesigenic choreoathetosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
All 6 cases presented with typical paroxysmal kinesigenic dyskinesia characteristics, except for the Dishevelled, Egl-10, and Pleckstrin domain containing 5 family, where the proband's mother had abnormal discharges in her temporal lobes in addition to paroxysmal kinesigenic dyskinesia episodes.
|
29356177 |
2018 |
|
Episodic Kinesigenic Dyskinesia 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
All 6 cases presented with typical paroxysmal kinesigenic dyskinesia characteristics, except for the Dishevelled, Egl-10, and Pleckstrin domain containing 5 family, where the proband's mother had abnormal discharges in her temporal lobes in addition to paroxysmal kinesigenic dyskinesia episodes.
|
29356177 |
2018 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.
|
26578795 |
2015 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.
|
31040156 |
2019 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
APC interacts with the Rac1-specific guanine-nucleotide exchange factor (GEF) Asef, which contains an APC-binding region (ABR) in addition to Dbl homology (DH), Pleckstrin (PH) and Src homology 3 (SH3) domains.
|
17599059 |
2007 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
As a multifunctional adaptor protein, APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and a leucine zipper motif 1) is overexpressed in many cancers, and has been implicated in tumorigenesis and tumor progression.
|
28902365 |
2017 |