PLN, phospholamban, 5350

N. diseases: 90; N. variants: 6
Disease: Heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE In contrast, steady-state levels of phospholamban mRNA decreased, whereas levels of beta-myosin heavy-chain mRNA were unchanged with heart failure. 2040039 1991
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE These data also show that the altered SR function in human heart failure cannot be explained by altered protein levels of PLB and SERCA2. 8689655 1996
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE The potential physiological relevance of PLB function in human heart failure is also covered. 9790566 1998
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE Phospholamban (PLB) inhibits SERCA2 activity and is therefore a potential target to improve the cardiac performance in heart failure. 10468529 1999
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE The ablation of a muscle-specific sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) inhibitor, phospholamban, rescued the spectrum of phenotypes that resemble human heart failure. 10555147 1999
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Phospholamban deficiency may prevent such left ventricular dysfunction and its progression to heart failure in some of the animal models with dilated cardiomyopathy. 11855657 2001
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Targeting phospholamban by gene transfer in human heart failure. 11864915 2002
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. 12134142 2002
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Transgenic PLN(R9C) mice recapitulated human heart failure with premature death. 12610310 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease LHGDN Transgenic PLN(R9C) mice recapitulated human heart failure with premature death. 12610310 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE In contrast to reported benefits of PLN ablation in mouse heart failure, humans lacking PLN develop lethal dilated cardiomyopathy. 12639993 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE In contrast, PLB, troponin I (TnI) and PP1 protein and TnI phosphorylation levels did not differ between HF and NF. 14732205 2004
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE We investigated whether genetic modification of calcium handling through deletion of phospholamban in mice would affect the development of heart failure in mice with transgenic overexpression of the beta1-adrenergic receptor. 14967726 2004
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE In contrast, transgenic mice that express an inducible Galpha q mutant that cannot activate phospholipase Cbeta (PLCbeta) do not develop heart failure or changes in PLB phosphorylation, but do show decreased L-type Ca2+ current density. 16210321 2005
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE Through genetic screening of dilated cardiomyopathy patients, we identified a previously uncharacterized deletion of arginine 14 (PLN-R14Del) in the coding region of the phospholamban (PLN) gene in a large family with hereditary heart failure. 16432188 2006
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Abnormalities in two proteins that regulate Ca(2+) handling in myocytes, phospholamban and the voltage-dependent L-type Ca(2+) channel, were also reversed, as was the increased expression of genes that are associated with heart failure. 16893886 2006
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE These findings suggest that the human G147D PPI-1 can attenuate responses of cardiomyocytes to beta-adrenergic agonists by decreasing PLN phosphorylation and therefore may contribute to deteriorated function in heart failure. 18192322 2008
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE These findings suggest that the g.203A>C genetic variant in the human PLN promoter may contribute to depressed contractility and accelerate functional deterioration in heart failure. 18241046 2008
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE The data demonstrate an association between the dose-dependent inhibition of SERCA2a activity by PLN(wt) and the time of onset of heart failure and show that a weak inhibitor of SERCA2a, PLN(R9C), which is diminished in its ability to modify the level of SERCA2a activity, leads to heart failure despite fast sarcoplasmic reticulum Ca(2+) reuptake. 19139388 2009
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE In this study, our objective was to determine the presence of the -36A>C alteration in PLN gene in a Brazilian population of individuals with HF and to test whether this alteration is associated with heart failure or with a worse prognosis of patients with HF. 19638213 2009
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE These results show that LOF PLB(M) can compete both physically and functionally with PLB(W), provide a rational explanation for the partial success of S16E-based gene therapy in animal models of heart failure, and establish a powerful platform for designing and testing more effective PLB(M) targeted for gene therapy of heart failure in humans. 21510919 2011
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE Mutations in the gene encoding PLN have been associated with idiopathic dilated cardiomyopathy; however, no systematic search for PLN mutations in heart failure has been conducted. 22137083 2011
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE These results establish this FRET assay as a rapid and quantitative means of screening PLB(M) for optimization of gene therapy to activate SERCA, as needed for gene therapy in HF. 22405774 2012
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE These results support the development of the PLN repressor as therapy for heart failure, and provide evidence that delivery of engineered ZFP TFs to native organs can drive therapeutically relevant levels of gene repression in vivo. 22828502 2012
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Therapeutic disease RGD Reversal of subcellular remodelling by losartan in heart failure due to myocardial infarction. 22947202 2012