PLN, phospholamban, 5350

N. diseases: 90; N. variants: 6
Disease: Heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Abnormalities in two proteins that regulate Ca(2+) handling in myocytes, phospholamban and the voltage-dependent L-type Ca(2+) channel, were also reversed, as was the increased expression of genes that are associated with heart failure. 16893886 2006
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE In contrast, transgenic mice that express an inducible Galpha q mutant that cannot activate phospholipase Cbeta (PLCbeta) do not develop heart failure or changes in PLB phosphorylation, but do show decreased L-type Ca2+ current density. 16210321 2005
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE In contrast, PLB, troponin I (TnI) and PP1 protein and TnI phosphorylation levels did not differ between HF and NF. 14732205 2004
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease BEFREE We investigated whether genetic modification of calcium handling through deletion of phospholamban in mice would affect the development of heart failure in mice with transgenic overexpression of the beta1-adrenergic receptor. 14967726 2004
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE In contrast to reported benefits of PLN ablation in mouse heart failure, humans lacking PLN develop lethal dilated cardiomyopathy. 12639993 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Transgenic PLN(R9C) mice recapitulated human heart failure with premature death. 12610310 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 GeneticVariation disease LHGDN Transgenic PLN(R9C) mice recapitulated human heart failure with premature death. 12610310 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. 12134142 2002
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Targeting phospholamban by gene transfer in human heart failure. 11864915 2002
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE Phospholamban deficiency may prevent such left ventricular dysfunction and its progression to heart failure in some of the animal models with dilated cardiomyopathy. 11855657 2001
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE Phospholamban (PLB) inhibits SERCA2 activity and is therefore a potential target to improve the cardiac performance in heart failure. 10468529 1999
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE The ablation of a muscle-specific sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) inhibitor, phospholamban, rescued the spectrum of phenotypes that resemble human heart failure. 10555147 1999
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease BEFREE The potential physiological relevance of PLB function in human heart failure is also covered. 9790566 1998
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE These data also show that the altered SR function in human heart failure cannot be explained by altered protein levels of PLB and SERCA2. 8689655 1996
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression disease BEFREE In contrast, steady-state levels of phospholamban mRNA decreased, whereas levels of beta-myosin heavy-chain mRNA were unchanged with heart failure. 2040039 1991