|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
PML-RARA fusion was detected with appropriate molecular probes in one patient with acute promyelocytic leukemia without t(15;17).
|
12699896 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The short form of PML-RARalpha transcripts was found more frequently in M3v (P < .002) and CD2+ APL (P < .0001) than in M3 and CD2- APL, respectively.The median follow-up was 128 weeks.
|
15023045 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
PML(NLS-) was detected in primary APL, but not non-APL cells.
|
28075463 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fourteen patients with PML/RARalpha-positive acute promyelocytic leukemia (APL) were given salvage therapy at the time of first molecular relapse.
|
10498592 |
1999 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia.
|
7680887 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In vitro experiments carried out on APL blasts demonstrate that transcription of these snoRNAs was lost under all-trans retinoic acid-mediated differentiation and induced by enforced expression of the PML-RARalpha fusion protein in negative leukemic cell lines.
|
22522792 |
2012 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The malignant cells of acute promyelocytic leukemia (APL) contain a reciprocal chromosomal translocation that fuses the promyelocytic leukemia gene (PML) with the retinoic acid receptor alpha gene (RAR alpha).
|
9122233 |
1997 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A complex translocation (1;17;15) with spliced short-type PML-RARA fusion transcripts in acute promyelocytic leukemia: A case report.
|
30680014 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, few studies have investigated whether BRD4 influenced acute promyelocytic leukemia (APL), and whether BRD4 had interaction with promyelocytic leukemia-retinoic acid receptor α (PML/RARα) fusion protein to some extent.
|
30552662 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The retinoic acid receptor alpha (RARA) gene is disrupted by PML/RARA fusion in acute promyelocytic leukemia (APL).
|
16239915 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Diagnosis and molecular monitoring of acute promyelocytic leukemia using DzyNA reverse transcription-PCR to quantify PML/RARalpha fusion transcripts.
|
12142392 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aberrant fusion PML-RARalpha protein remains sensitive to ATRA and underlies the pathogenesis of the APL.
|
11060680 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Most acute promyelocytic leukemia (APL) cases have t(15;17)(q22;q21) chromosomal translocation and PML-RARalpha chimeric gene which blocks granulocytic differentiation.
|
12642682 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by a chromosomal t(15;17) translocation that fuses the gene encoding the promyelocytic leukemia protein (PML) to that encoding retinoic acid receptor alpha (RARA).
|
20724820 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In patients with acute promyelocytic leukemia (APL), the RARalpha gene is fused with the promyelocytic leukemia (PML) gene via the t(15;17) translocation, resulting in the expression of a PML/RARalpha fusion protein.
|
18212063 |
2008 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
This observation, which highlights the importance of PML, is likely to be a key to unravelling the molecular mechanism of both leukemogenesis and RA-induced differentiation of APL.
|
8400236 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genetic hallmark of APL is a balanced translocation involving chromosomes 15 and 17, and the PML-RARa gene fusion is found in more than 90% of these cases.
|
23363773 |
2013 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic leukemia-retinoic acid receptor α (PML-RARA) fusion oncogene.
|
21436584 |
2011 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Section of Hematology, Department of Pathology and Laboratory Medicine at King Faisal Specialist Hospital and Research Center has shared this experience during the last 10 years with more than 6,546 samples submitted for the analysis of different gene rearrangements, fusion gene transcripts and gene mutations including Ig heavy chain gene rearrangement for B-cell malignancies, T-cell receptor gamma chain gene rearrangement for T-cell malignancies, BCR/ABL-P210 and P190 fusion gene transcripts, for chronic myeloid leukemia and Philadelphia positive acute lymphoblastic leukemia, PML/RARalpha fusion gene for promyelocytic leukemia, AML1/ETO for acute myeloid leukemia AML-M2 with t8;21, CBFB/MYH11 for AML M4E0 with inv 16, BCL-2 for follicular lymphoma, and BCL-1 for mantle cell lymphoma.
|
16228048 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, PCR analysis using genomic DNA of APL cells is proved to be useful for identifying the breakpoints of the PML and the RARA genes.
|
8385082 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
LHGDN |
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
|
11891284 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
ATRA-induced Pin1 ablation degrades the protein encoded by the fusion oncogene PML-RARA and treats APL in APL cell and animal models as well as in human patients.
|
25849135 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
We identified DNA sequence variations resulting in a truncated PML protein in APL cases that displayed RA resistance and a very poor prognosis.
|
14630830 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our findings indicate that FOXC1 is consistently repressed in APL due to hypermethylation and the presence of the PML-RARA rearrangement.
|
29137406 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is due to a chromosomal t(15;17) translocation which involves a novel human gene, Myl, (also named PML) and the retinoic acid (RA) receptor alpha (RAR-alpha) gene.
|
1311253 |
1992 |