TLR9, toll like receptor 9, 54106

N. diseases: 457; N. variants: 11
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 AlteredExpression disease BEFREE The expression of TLR9 was measured in different CRC cell lines and cancerous samples by RT-PCR or immunohistochemistry, which showed that high expression of TLR9 was significantly correlated with the tumor metastasis, advanced TNM stage and poor prognosis of patients. 30239551 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 AlteredExpression disease BEFREE With the signal activation, the levels of TLR9 protein raised more in advanced colorectal cancer than in early colorectal cancer. 30271180 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease BEFREE The detection of higher frequencies of the TLR2, TLR4 and/or TLR9 polymorphisms in CRC patients compared with the control groups highlight the role of these polymorphism in CRC development and cancer progression. 29883450 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 AlteredExpression disease BEFREE Cell membrane and intracellular expression of toll-like receptor 9 (TLR9) in colorectal cancer and breast cancer cell-lines. 28106541 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 Biomarker disease BEFREE The results cast doubt on the usefulness of TLR9 agonist in treating colorectal cancer. 25546690 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 AlteredExpression disease BEFREE TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC. 22371291 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease UNIPROT