TLR9, toll like receptor 9, 54106

N. diseases: 457; N. variants: 11
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 AlteredExpression disease BEFREE Inflamed CD ileal and UC mucosa showed increased IL23A, while only inflamed CD ileal samples showed increased TLR9 mRNA level. 30193869 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 GeneticVariation disease BEFREE Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05). 24776844 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 GeneticVariation disease BEFREE The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC. 24971461 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 GeneticVariation disease BEFREE Our results provide evidence for genetic interactions between polymorphisms in TLR9 and CD-associated variants in NOD2, IL23R, and DLG5, differentially modulating CD susceptibility. 19455129 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 GeneticVariation disease BEFREE Nevertheless, the significance of the TLR4 299G and TLR9-1237C associations with CD worldwide was confirmed by a meta-analysis test using our datasets and datasets from previously published studies. 17914947 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 Biomarker disease CTD_human Nevertheless, the significance of the TLR4 299G and TLR9-1237C associations with CD worldwide was confirmed by a meta-analysis test using our datasets and datasets from previously published studies. 17914947 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 Biomarker disease BEFREE Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. 15928043 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 AlteredExpression disease BEFREE TLR9 mRNA was equally expressed in colonic mucosa from controls (n = 6) and patients with ulcerative colitis or Crohn's disease disease (n = 13). 15996194 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004