|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasmodium DNA-mediated TLR9 activation of T-bet<sup>+</sup> B cells contributes to autoimmune anaemia during malaria.
|
29101363 |
2017 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further, clinical outcome in malaria was observed to be apparently modulated by LD between TLR9 promoter variants.
|
26462624 |
2015 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Austro-Asiatics appeared to have accumulated favourable genotypes of TLR9, perhaps because of their longer exposure to malaria.
|
22948021 |
2013 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four TLR9 single nucleotide polymorphisms (SNPs) namely: rs187084 (C-1486 T), rs5743836(C-1237 T), rs352139 (G + 1174A) and rs352140 (G + 2848A) were genotyped by direct sequencing, and their attributable and relative risks for symptomatic malaria determined.
|
22594374 |
2012 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR9 T1237C rs5743836CC was associated with an increased risk of developing malaria (p=0.03), although it was found with the same frequency in uncomplicated and severe malaria cases.
|
22691414 |
2012 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results corroborated the involvement of TLR9 in CM pathogenesis and suggest that interference with the activation of this receptor is a promising strategy to prevent deleterious inflammatory response mediating pathogenesis and severity of malaria.
|
22659438 |
2012 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although Toll-like receptor 9 (TLR9) has been implicated in cytokine and type I interferon (IFN) production during malaria in humans and mice, the high AT content of the Plasmodium falciparum genome prompted us to examine the possibility that malarial DNA triggered TLR9-independent pathways.
|
21820332 |
2011 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No convincing association was found with polymorphisms in TLR9 for malaria severity, in either Gambian or Malawian populations, using both case-control and family based study designs.
|
19284650 |
2009 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Patients with severe and mild malaria showed increased surface expression of TLR2 and TLR4 on CD14(+)monocytes and myeloid dendritic cells (MDCs) and decreased intracellular expression of TLR9 on plasmacytoid dendritic cells (PDCs), compared to those of healthy controls.
|
17854755 |
2008 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
|
17261807 |
2007 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that TLR4 and TLR9 play a role in the manifestation of malaria during pregnancy.
|
16779724 |
2006 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two frequent TLR-9 promoter polymorphisms did not show a clear association with malaria severity.
|
16371473 |
2006 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway.
|
15067072 |
2004 |