Crohn Disease
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Inflamed CD ileal and UC mucosa showed increased IL23A, while only inflamed CD ileal samples showed increased TLR9 mRNA level.
|
30193869 |
2018 |
Crohn Disease
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
Crohn Disease
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
Crohn Disease
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence for genetic interactions between polymorphisms in TLR9 and CD-associated variants in NOD2, IL23R, and DLG5, differentially modulating CD susceptibility.
|
19455129 |
2009 |
Crohn Disease
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, the significance of the TLR4 299G and TLR9-1237C associations with CD worldwide was confirmed by a meta-analysis test using our datasets and datasets from previously published studies.
|
17914947 |
2007 |
Crohn Disease
|
0.370 |
Biomarker
|
disease |
CTD_human |
Nevertheless, the significance of the TLR4 299G and TLR9-1237C associations with CD worldwide was confirmed by a meta-analysis test using our datasets and datasets from previously published studies.
|
17914947 |
2007 |
Crohn Disease
|
0.370 |
Biomarker
|
disease |
BEFREE |
Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease.
|
15928043 |
2005 |
Crohn Disease
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
TLR9 mRNA was equally expressed in colonic mucosa from controls (n = 6) and patients with ulcerative colitis or Crohn's disease disease (n = 13).
|
15996194 |
2005 |
Crohn Disease
|
0.370 |
Biomarker
|
disease |
CTD_human |
Crohn's disease is associated with a toll-like receptor-9 polymorphism.
|
15236225 |
2004 |
Colorectal Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The expression of TLR9 was measured in different CRC cell lines and cancerous samples by RT-PCR or immunohistochemistry, which showed that high expression of TLR9 was significantly correlated with the tumor metastasis, advanced TNM stage and poor prognosis of patients.
|
30239551 |
2018 |
Colorectal Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
With the signal activation, the levels of TLR9 protein raised more in advanced colorectal cancer than in early colorectal cancer.
|
30271180 |
2018 |
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The detection of higher frequencies of the TLR2, TLR4 and/or TLR9 polymorphisms in CRC patients compared with the control groups highlight the role of these polymorphism in CRC development and cancer progression.
|
29883450 |
2018 |
Colorectal Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Cell membrane and intracellular expression of toll-like receptor 9 (TLR9) in colorectal cancer and breast cancer cell-lines.
|
28106541 |
2017 |
Colorectal Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
The results cast doubt on the usefulness of TLR9 agonist in treating colorectal cancer.
|
25546690 |
2014 |
Colorectal Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC.
|
22371291 |
2012 |
Colorectal Carcinoma
|
0.360 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Inflammation
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation.
|
19797157 |
2009 |
Inflammation
|
0.310 |
Biomarker
|
phenotype |
LHGDN |
These findings suggest that tubular TLR-9 activation has a pathogenetic role in tubulointerstitial inflammation and damage in experimental and human lupus nephritis, and they indicate a novel target for future therapies.
|
17469139 |
2007 |
Granuloma, Foreign-Body
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation.
|
19797157 |
2009 |
Granuloma, Respiratory Tract
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation.
|
19797157 |
2009 |
Schistosomiasis mansoni
|
0.300 |
Biomarker
|
disease |
CTD_human |
Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation.
|
19797157 |
2009 |
Intestinal schistosomiasis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation.
|
19797157 |
2009 |
Crohn's disease of large bowel
|
0.300 |
Biomarker
|
disease |
CTD_human |
TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.
|
17914947 |
2007 |
Crohn's disease of the ileum
|
0.300 |
Biomarker
|
disease |
CTD_human |
TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.
|
17914947 |
2007 |
Regional enteritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.
|
17914947 |
2007 |