TLR9, toll like receptor 9, 54106

N. diseases: 457; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 AlteredExpression disease BEFREE Inflamed CD ileal and UC mucosa showed increased IL23A, while only inflamed CD ileal samples showed increased TLR9 mRNA level. 30193869 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 GeneticVariation disease BEFREE Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05). 24776844 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 GeneticVariation disease BEFREE The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC. 24971461 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 GeneticVariation disease BEFREE Our results provide evidence for genetic interactions between polymorphisms in TLR9 and CD-associated variants in NOD2, IL23R, and DLG5, differentially modulating CD susceptibility. 19455129 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 GeneticVariation disease BEFREE Nevertheless, the significance of the TLR4 299G and TLR9-1237C associations with CD worldwide was confirmed by a meta-analysis test using our datasets and datasets from previously published studies. 17914947 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 Biomarker disease CTD_human Nevertheless, the significance of the TLR4 299G and TLR9-1237C associations with CD worldwide was confirmed by a meta-analysis test using our datasets and datasets from previously published studies. 17914947 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 Biomarker disease BEFREE Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. 15928043 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 AlteredExpression disease BEFREE TLR9 mRNA was equally expressed in colonic mucosa from controls (n = 6) and patients with ulcerative colitis or Crohn's disease disease (n = 13). 15996194 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.370 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 AlteredExpression disease BEFREE The expression of TLR9 was measured in different CRC cell lines and cancerous samples by RT-PCR or immunohistochemistry, which showed that high expression of TLR9 was significantly correlated with the tumor metastasis, advanced TNM stage and poor prognosis of patients. 30239551 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 AlteredExpression disease BEFREE With the signal activation, the levels of TLR9 protein raised more in advanced colorectal cancer than in early colorectal cancer. 30271180 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 GeneticVariation disease BEFREE The detection of higher frequencies of the TLR2, TLR4 and/or TLR9 polymorphisms in CRC patients compared with the control groups highlight the role of these polymorphism in CRC development and cancer progression. 29883450 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 AlteredExpression disease BEFREE Cell membrane and intracellular expression of toll-like receptor 9 (TLR9) in colorectal cancer and breast cancer cell-lines. 28106541 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 Biomarker disease BEFREE The results cast doubt on the usefulness of TLR9 agonist in treating colorectal cancer. 25546690 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 AlteredExpression disease BEFREE TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC. 22371291 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 GeneticVariation disease UNIPROT
CUI: C0021368
Disease: Inflammation
Inflammation
0.310 Biomarker phenotype CTD_human Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation. 19797157 2009
CUI: C0021368
Disease: Inflammation
Inflammation
0.310 Biomarker phenotype LHGDN These findings suggest that tubular TLR-9 activation has a pathogenetic role in tubulointerstitial inflammation and damage in experimental and human lupus nephritis, and they indicate a novel target for future therapies. 17469139 2007
CUI: C0018193
Disease: Granuloma, Foreign-Body
Granuloma, Foreign-Body
0.300 Biomarker phenotype CTD_human Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation. 19797157 2009
CUI: C0018200
Disease: Granuloma, Respiratory Tract
Granuloma, Respiratory Tract
0.300 Biomarker phenotype CTD_human Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation. 19797157 2009
CUI: C0036330
Disease: Schistosomiasis mansoni
Schistosomiasis mansoni
0.300 Biomarker disease CTD_human Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation. 19797157 2009
CUI: C0242497
Disease: Intestinal schistosomiasis
Intestinal schistosomiasis
0.300 Biomarker disease CTD_human Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation. 19797157 2009
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel
0.300 Biomarker disease CTD_human TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. 17914947 2007
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum
0.300 Biomarker disease CTD_human TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. 17914947 2007
CUI: C0678202
Disease: Regional enteritis
Regional enteritis
0.300 Biomarker disease CTD_human TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. 17914947 2007