TLR9, toll like receptor 9, 54106

N. diseases: 457; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE This finding together with reduced cytokine production upon TLR9 activation appears to mark postactivated lupus B cells. 30540579 2019
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE Our observations provide new insights about the MZ B cell translocation in lupus patients as well as the dichotomy of TLR9 and TLR7 signals in the pathogenesis of lupus. 30286201 2018
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE This study was undertaken to examine the suppressive role of TLR-9 in the development of severe lupus in a mouse model. 29687651 2018
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 AlteredExpression disease BEFREE These findings suggest a unique link between neutrophils and B cells in which NETs trigger a concerted activation of TLR9 and BCR leading to anti-NET autoantibody production in lupus. 29632142 2018
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice. 28278279 2017
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE The ability of TLR9 to detect and elicit an immune response against double-stranded DNA makes TLR9 a relevant factor to be tested for its association with the clinical and serological phenotypes of lupus. 27432810 2017
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 GeneticVariation disease BEFREE Hence, this study was carried out to analyze the G to A and C to T transitions in TLR2 and TLR9 genes respectively and to test their association with lupus susceptibility, clinical and autoantibody phenotypes in South Indian Tamils. 25466615 2015
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 AlteredExpression disease BEFREE African American women with lupus had a 2-fold increase in TLR-9 expression level when compared to their healthy controls or European American lupus patients. 24865418 2014
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE Role of TLR9 has been elegantly demonstrated in both human systemic lupus erythematosus (SLE) and mice model of lupus. 23974051 2013
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE Thus, IFN-I signaling is an important mediator of lupus pathogenesis and anti-RNA Ab production that is dysregulated in the absence of Tlr9. 23467932 2013
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 AlteredExpression disease BEFREE TLR9 expression was positively correlated with fever (P = 0.017), alopecia (P = 0.046), safety of estrogens in lupus erythematosus national assessment SLE disease activity index (SELENA-SLEDAI) score (r(s) = 0.385, P = 0.003), and the level of IRF5 (r(s) = 0.35, P = 0.027) and IFN-a (r(s) = 0.627, P = 0.001) in SLE patients. 22932083 2012
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE These results demonstrate that both TLR9 and TLR4 are required for 'full-blown' autoimmunity and organ injury in experimental lupus induced by pristane. 20810248 2010
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 AlteredExpression disease BEFREE And the increase of the co-expression of TLR9 and T-bet may be of benefit to the protective antibodies' production and pathogenic antibodies' decline, and could be regarded as a good sign for lupus demission and/or treatment. 19362685 2009
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 AlteredExpression disease BEFREE These results suggest that up-regulated expression of TLR7 and TLR9 mRNAs together with increased expression of IFN-alpha mRNA in PBMCs may also contribute to the pathogenesis of human lupus. 18373699 2008
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE Toll-like receptor 9 in murine lupus: more friend than foe! 18241699 2008
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE In this review, we discuss the rationale for self-recognition by TLR7 and TLR9 as an important part of the development of lupus and other autoimmune diseases. 18613842 2008
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE DNA-containing immune complexes purified from sera of patients with lupus induced TLR-9 in cultured proximal tubular cells. 17469139 2007
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. 18034431 2007
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. 16973389 2006
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus
0.100 Biomarker disease BEFREE We show that in TLR9-deficient lupus-prone mice, the generation of anti-dsDNA and antichromatin autoantibodies is specifically inhibited. 16027240 2005