|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, we discuss possible mechanisms whereby these histone/protein deacetylases facilitate the switch between DNA double-strand break (DSB) repair pathways, how SIRTs play a central role in the crosstalk between DNA repair and cell death pathways due to their dependence on NAD<sup>+</sup>, and the influence of small molecule HDAC inhibitors (HDACi) on cancer cell resistance to genotoxin based therapies.
|
27738139 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, we discuss possible mechanisms whereby these histone/protein deacetylases facilitate the switch between DNA double-strand break (DSB) repair pathways, how SIRTs play a central role in the crosstalk between DNA repair and cell death pathways due to their dependence on NAD<sup>+</sup>, and the influence of small molecule HDAC inhibitors (HDACi) on cancer cell resistance to genotoxin based therapies.
|
27738139 |
2016 |
|
Malignant Neoplasms
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
Epigenetic dysregulation is a hallmark of cancer executed by a number of complex processes the most important of which converge on DNA methylation and histone protein modifications.
|
26520622 |
2015 |
|
Primary malignant neoplasm
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
Epigenetic dysregulation is a hallmark of cancer executed by a number of complex processes the most important of which converge on DNA methylation and histone protein modifications.
|
26520622 |
2015 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The retinoblastoma protein-interacting zinc finger gene RIZ1 is a tumor suppressor gene and a member of a nuclear histone/protein methyltransferase superfamily.
|
20159667 |
2010 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The retinoblastoma protein-interacting zinc finger gene RIZ1 is a tumor suppressor gene and a member of a nuclear histone/protein methyltransferase superfamily.
|
11719434 |
2001 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histone Protein Epitope Mapping for Autoantibody Recognition in Rheumatoid Arthritis.
|
30539581 |
2019 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our finding implicates the deficiency of H1 linker histone protein in autism.
|
29704315 |
2018 |
|
Diabetes
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Histone protein phosphorylation should be borne in mind when considering epigenetic targets amenable to therapeutic manipulation in diabetes.
|
30213824 |
2018 |
|
Diabetes Mellitus
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Histone protein phosphorylation should be borne in mind when considering epigenetic targets amenable to therapeutic manipulation in diabetes.
|
30213824 |
2018 |
|
Diabetic Nephropathy
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
These findings demonstrate the influence that histone protein phosphorylation may have on gene activation in diabetic kidney disease.
|
30213824 |
2018 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia.
|
28054944 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) there is a relative paucity of reports on the role of histone protein modifications (acetylation, methylation, phosphorylation) as compared to acute myeloid leukemia, T-cell ALL, or other hematologic cancers, and in this setting chromatin modifications are relatively less well studied and reviewed than DNA methylation.
|
28054944 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the expression and prognostic significance of histone protein variants in PDAC patients.
|
29197353 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia.
|
28054944 |
2017 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Seven studies reported histone protein alterations in AD and PD.
|
27973581 |
2016 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Seven studies reported histone protein alterations in AD and PD.
|
27973581 |
2016 |
|
Chronic Obstructive Airway Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated colocalization of γ-histone protein 2A.X and telomeres and telomere length in small airway epithelial cells from patients with COPD, during murine lung aging, and following cigarette smoke exposure in vivo and in vitro.
|
26386121 |
2015 |
|
leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
More interestingly, the methylation status of histone protein H3K4 (H3 at lysine 4) with E2 is much higher than without E2 treatment in leukaemia cell.
|
25307539 |
2014 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SIRT1, a nicotinamide adenine dinucleotide(+)-dependent histone/protein deacetylase, plays a crucial role in various physiological processes, such as aging, metabolism, neurogenesis and apoptosis, owing to its ability to deacetylate numerous substrates, such as histone and NF-κB, which is implicated as an exacerbation factor in ATL.
|
22322739 |
2012 |
|
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
H2AX, an essential histone protein, is phosphorylated by ATM in response to double-strand breaks, and H2AX-deficient mice share some clinical and laboratory findings with AT.
|
21199394 |
2011 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A consistent observation among the GWAS studies is the association with schizophrenia of genetic markers in the major histocompatibility complex (6p22.1)-containing genes including NOTCH4 and histone protein loci.
|
20954426 |
2010 |
|
Blast Phase
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the possible contribution of dysfunction of Bcl11b, a zinc-finger protein required for thymocyte differentiation, and of H2AX, a histone protein involved in DNA repair, to the transition from CML CP to BC.
|
19432895 |
2009 |
|
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the possible contribution of dysfunction of Bcl11b, a zinc-finger protein required for thymocyte differentiation, and of H2AX, a histone protein involved in DNA repair, to the transition from CML CP to BC.
|
19432895 |
2009 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Three genes, BACH1, TP53BPL, and H2B/S, were consistently expressed as a significant cluster associated with the low-risk ALL subgroups.
|
12970791 |
2003 |