PODXL, podocalyxin like, 5420

N. diseases: 156; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 Biomarker disease BEFREE Podocalyxin (Podxl) is a CD34 orthologue and cell surface sialomucin reported to have roles in renal podocyte diaphragm slit development; vascular cell integrity; and the progression of blood, breast, and prostate cancers. 28408238 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 AlteredExpression disease BEFREE Overexpression of podocalyxin in prostate cancer renders the protein a putative immunohistochemical marker of prostate cancer that may contribute to stratification of patients for optimal treatment. 30396958 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 Biomarker disease CTD_human These results implicate PODXL as a candidate prostate cancer tumor aggressiveness gene mapping to chromosome 7q32-q33. 16434482 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 Biomarker disease BEFREE These results implicate PODXL as a candidate prostate cancer tumor aggressiveness gene mapping to chromosome 7q32-q33. 16434482 2006
CUI: C3501848
Disease: Nephrosis, congenital
Nephrosis, congenital 		0.310 Biomarker disease GENOMICS_ENGLAND Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis. 24048372 2014
CUI: C3501848
Disease: Nephrosis, congenital
Nephrosis, congenital 		0.310 Biomarker disease GENOMICS_ENGLAND Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management. 28117080 2017
CUI: C3501848
Disease: Nephrosis, congenital
Nephrosis, congenital 		0.310 Biomarker disease BEFREE Loss of podocalyxin causes a novel syndromic type of congenital nephrotic syndrome. 29244787 2017
CUI: C0577631
Disease: Carotid Atherosclerosis
Carotid Atherosclerosis 		0.300 Biomarker disease CTD_human Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes. 22016802 2011
CUI: C0750987
Disease: Arterial Diseases, Common Carotid
Arterial Diseases, Common Carotid 		0.300 Biomarker disease CTD_human Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes. 22016802 2011
CUI: C4510873
Disease: Atypical juvenile parkinsonism
Atypical juvenile parkinsonism 		0.300 GermlineCausalMutation disease ORPHANET Discovery of a frameshift mutation in podocalyxin-like (PODXL) gene, coding for a neural adhesion molecule, as causal for autosomal-recessive juvenile Parkinsonism. 26864383 2016
CUI: C1868675
Disease: PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE
PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE 		0.110 GeneticVariation disease BEFREE Discovery of a frameshift mutation in podocalyxin-like (PODXL) gene, coding for a neural adhesion molecule, as causal for autosomal-recessive juvenile Parkinsonism. 26864383 2016
CUI: C1868675
Disease: PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE
PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE 		0.110 GeneticVariation disease CLINVAR Discovery of a frameshift mutation in podocalyxin-like (PODXL) gene, coding for a neural adhesion molecule, as causal for autosomal-recessive juvenile Parkinsonism. 26864383 2016
CUI: C0003467
Disease: Anxiety
Anxiety 		0.100 Biomarker disease HPO
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 Biomarker disease HPO
CUI: C0013363
Disease: Dysautonomia
Dysautonomia 		0.100 Biomarker disease HPO
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.100 Biomarker disease HPO
CUI: C0018524
Disease: Hallucinations
Hallucinations 		0.100 Biomarker disease HPO
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.100 Biomarker disease HPO
CUI: C0036439
Disease: Scoliosis, unspecified
Scoliosis, unspecified 		0.100 Biomarker disease HPO
CUI: C0039273
Disease: Talipes cavus
Talipes cavus 		0.100 Biomarker disease HPO
CUI: C0085623
Disease: Akinesia
Akinesia 		0.100 Biomarker disease HPO
CUI: C0086769
Disease: Panic Attacks
Panic Attacks 		0.100 Biomarker disease HPO
CUI: C0150080
Disease: Social Communication Disorder
Social Communication Disorder 		0.100 Biomarker disease HPO
CUI: C0152020
Disease: Gastroparesis
Gastroparesis 		0.100 Biomarker disease HPO
CUI: C0234517
Disease: Anarthria speech disorder
Anarthria speech disorder 		0.100 Biomarker disease HPO