CYCS, cytochrome c, somatic, 54205

N. diseases: 67; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2677608
Disease: Thrombocytopenia 4
Thrombocytopenia 4
0.710 Biomarker disease CTD_human
CUI: C2677608
Disease: Thrombocytopenia 4
Thrombocytopenia 4
0.710 CausalMutation disease CLINVAR
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.650 Biomarker phenotype HPO
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma
0.030 AlteredExpression disease BEFREE Chorionic somatomammotropin (hCS) genes (hCS-A and hCS-B) and the placental growth hormone variant (hGH-V) gene are expressed in the syncytiotrophoblast in vivo, and at low levels in cytotrophoblast-like choriocarcinoma (BeWo) cells. 8472847 1993
CUI: C0008479
Disease: Chondrosarcoma
Chondrosarcoma
0.050 Biomarker disease BEFREE HCS-2/8 is a stable human chondrosarcoma cell line with many chondrocytic characteristics and has the capacity to form chondrosarcomas in nude mice. 8200849 1994
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma
0.030 AlteredExpression disease BEFREE We demonstrated that TEF-1 represses hCS promoter activity in choriocarcinoma (BeWo) cells (Jiang, S.W., and Eberhardt, N.L.(1995) J. Biol.Chem. 8621623 1996
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma
0.030 AlteredExpression disease BEFREE Each individual concatenated enhanson was able to stimulate hCS promoter activity in an orientation-independent manner in choriocarcinoma cells (BeWo) with an observed stimulation that was directly proportional to its relative binding affinity for TEF-1 and CSEF-1. 9259314 1997
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.300 Biomarker disease CTD_human Mitochondrial adaptations to obesity-related oxidant stress. 10860543 2000
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.300 Biomarker disease CTD_human Mitochondrial adaptations to obesity-related oxidant stress. 10860543 2000
CUI: C0005818
Disease: Blood Platelet Disorders
Blood Platelet Disorders
0.010 Biomarker group BEFREE This study of a family with the platelet disorder characterized by a defect of the platelet P2(CYC) receptor supports our hypothesis that the full complement of the platelet ADP receptors is essential for normal platelet secretion and that some patients with the common, ill-defined diagnosis of PSD are actually heterozygous for the defect. 11073862 2000
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Posterior Circulation Transient Ischemic Attack
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Carotid Circulation Transient Ischemic Attack
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Transient Ischemic Attack, Vertebrobasilar Circulation
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Crescendo Transient Ischemic Attacks
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
CUI: C0751022
Disease: Brain Stem Ischemia, Transient
Brain Stem Ischemia, Transient
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
CUI: C0917805
Disease: Transient Cerebral Ischemia
Transient Cerebral Ischemia
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Transient Ischemic Attack, Anterior Circulation
0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
CUI: C0008479
Disease: Chondrosarcoma
Chondrosarcoma
0.050 Biomarker disease BEFREE Cell density-dependent proliferative effects of transforming growth factor (TGF)-beta 1, beta 2, and beta 3 in human chondrosarcoma cells HCS-2/8 are associated with changes in the expression of TGF-beta receptor type I. 11458815 2001
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. 11756504 2002
CUI: C0917798
Disease: Cerebral Ischemia
Cerebral Ischemia
0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. 11756504 2002
CUI: C0022116
Disease: Ischemia
Ischemia
0.300 Biomarker phenotype CTD_human Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury. 15172883 2004
CUI: C0008479
Disease: Chondrosarcoma
Chondrosarcoma
0.050 Biomarker disease BEFREE New clonal-cell lines HCS-TG C3 and E2 derived from human chondrosarcoma are morphologically chondrocytic in serial monolayer cultures and express chondrocytic phenotypes. 15118855 2004
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease CTD_human Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice. 16317704 2005
CUI: C0859021
Disease: Hyperthymic state
Hyperthymic state
0.010 GeneticVariation disease BEFREE PCAs showed the presence of a global major factor for each clinician-rated subscale with respective eigenvalues of the correlation matrices as follows: 7.1 for HYP-T, 6.0 for DEP-T, and 4.7 for CYC-T. 15780673 2005