Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Two variants in SORL1 and TREM2 were identified that were associated with Alzheimer's disease.
|
31217084 |
2020 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results provide insight into TREM2-related mechanisms that may be associated with AD in humans and may aid future development of disease-modifying pharmacological treatments targeting TREM2.
|
31727362 |
2020 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor that mediates the degradation disorder of amyloid β (Aβ) in Alzheimer's disease.
|
31833018 |
2020 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results, suggest that a p.(Gly145Trp)-induced structural disturbance and functional impairment of TREM2 may contribute to the pathogenesis of an AD-like form of dementia.
|
31464095 |
2020 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Several risk genes, such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD, but also many risk factors associated with life style (e.g., diabetes, hypercholesterolemia, stress) may play a role.
|
31571648 |
2020 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A rare variant in TREM2 (p.R47H, rs75932628) has been consistently reported to increase the risk for Alzheimer disease (AD), while mixed evidence has been reported for association of the variant with other neurodegenerative diseases.
|
31513029 |
2020 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.
|
30797549 |
2020 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Finally, constitutive deletion of Rev-erbα in the 5XFAD model of AD decreased amyloid plaque number and size and prevented plaque-associated increases in disease-associated microglia markers including TREM2, CD45, and Clec7a.
|
31800167 |
2020 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results, suggest that a p.(Gly145Trp)-induced structural disturbance and functional impairment of TREM2 may contribute to the pathogenesis of an AD-like form of dementia.
|
31464095 |
2020 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A novel homozygous mutation in TREM2 found in a Chinese early-onset dementia family with mild bone involvement.
|
30797549 |
2020 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.
|
30705288 |
2019 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The triggering receptor expressed on myeloid cells 2 (TREM2) gene has been reported to increase the risk of Alzheimer's disease (AD).
|
31204042 |
2019 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Massive parallel sequencing recently allowed the identification of three genes carrying a higher burden of rare, protein-truncating and missense predicted damaging variants in Alzheimer disease (AD) cases as compared to controls: TREM2, SORL1, and ABCA7.
|
30911827 |
2019 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We analyzed RNA-Seq data from parietal lobe brain tissue from AD cases with TREM2 variants (n = 33), AD cases (n = 195) and healthy controls (n = 118), from three independent datasets using Kallisto and the R package tximport to determine the read count for each transcript and quantified transcript abundance as transcripts per million.
|
31068200 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
(2019) demonstrate opposing effects of CD33 and TREM2 on AD phenotypes, where CD33 deletion promotes neuroprotection in a manner dependent on TREM2.
|
31487521 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood.
|
31413141 |
2019 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A cross-sectional study of 1027 participants of the Alzheimer's Disease Imaging Initiative (ADNI) cohort, including 43 subjects carrying TREM2 rare genetic variants, was conducted to measure CSF sTREM2 using a previously validated enzyme-linked immunosorbent assay (ELISA).
|
30630532 |
2019 |
Alzheimer's Disease
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
It is shown that the presence of the APOE ε4 allele, altered miRNA expression and epigenetic dysregulation in the promoter region and exon 1 of TREM2, as well as ANK1 hypermethylation and altered levels of histone post-translational methylation leading to increased transcription of TNFA, could variously explain increased levels of peripheral and central inflammation found in AD.
|
29705945 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease.
|
31462511 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer's disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem human AD brain.
|
30283031 |
2019 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variants of triggering receptor expressed on myeloid cells 2 (TREM2) are associated with an increased incidence of Alzheimer's disease, as well as other neurodegenerative disorders.
|
31101881 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum.
|
30458365 |
2019 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> rs9357347 located at the triggering receptor expressed on myeloid cells (<i>TREM</i>) gene cluster could increase TREM2 and TREM-like transcript 1 (TREML1) brain gene expression, which is considered to play a protective role against Alzheimer's disease (AD).
|
31379492 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have employed an ectopic model of TREM2 and DAP12 expression in HEK293 cells to study selectively TREM2 dependent signaling and phagocytic functions and evaluated the effects of some of the TREM2 mutations associated with AD.
|
31649511 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
|
30911003 |
2019 |