|
Lymphopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified a missense mutation (c. 3178C>T; p.R1060C) in POLD1 in 3 related subjects who presented with recurrent, especially herpetic, infections and T-cell lymphopenia with impaired T-cell but not B-cell proliferation.
|
31629014 |
2020 |
|
Primary immune deficiency disorder
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We sought to establish the role of DNA polymerase δ1 catalytic subunit (POLD1) as the cause of a primary immunodeficiency in an extended kindred.
|
31629014 |
2020 |
|
T-lymphocyte immunodeficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results identify gene defects in POLD1 as a novel cause of T-cell immunodeficiency.
|
31629014 |
2020 |
|
Enterovirus Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the fall of 2014, an outbreak of enterovirus D68 (EV-D68)-associated acute respiratory illness (ARI) occurred in the United States (1,2); before 2014, EV-D68 was rarely reported to CDC (2,3).
|
30921299 |
2019 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
In steady state conditions human liver LN contain relatively low numbers of cDC2, PDC, and macrophages, and relative numbers of cDC1 in liver LN decline during liver inflammation.
|
30930897 |
2019 |
|
Mediastinitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Between July 2010 and July 2016, poststernotomy patients with DSWI and mediastinitis underwent a secondary wound closure with modified BPMMF (Group A, center for disease control class (CDC)-II, n = 21; Group B, CDC-III, n = 20) or with OF (Group C, CDC-III, n = 19) following vacuum-assisted closure (VAC).
|
30404980 |
2019 |
|
Premature Menopause
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MB-MSCs combined with BSTCR improved the ovarian function of epirubicin induced POF mice, which might be related to the inhibition of GADD45b expression and the promotion of CyclinB1 and CDC2 expressions.
|
31311554 |
2019 |
|
Ovarian Failure, Premature
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MB-MSCs combined with BSTCR improved the ovarian function of epirubicin induced POF mice, which might be related to the inhibition of GADD45b expression and the promotion of CyclinB1 and CDC2 expressions.
|
31311554 |
2019 |
|
Orbital Pseudotumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation.
|
31841217 |
2019 |
|
Primary Sjögren's syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusions:</b> The decreased expression of miR-130a and miR-708 in pSS cDC2s seems to reflect cell activation. miR-130a targets MSK1, which regulates pro-inflammatory cytokine production, and we provide proof-of-concept for MSK1-inhibition as a therapeutic avenue to impede cDC2 activity in pSS.
|
31281310 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
VERU-111 arrested the cell cycle in the G2/M phase and induced apoptosis in PanCa cell lines via modulation of cell cycle regulatory (Cdc2, Cdc25c, and Cyclin B1) and apoptosis - associated (Bax, Bad, Bcl-2, and Bcl-xl) proteins.
|
30674344 |
2019 |
|
Orbital lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation.
|
31841217 |
2019 |
|
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The cognitive impairment in AD patients and SAMP8 mice was associated with reduced POLD1 expression.
|
30978525 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
VERU-111 arrested the cell cycle in the G2/M phase and induced apoptosis in PanCa cell lines via modulation of cell cycle regulatory (Cdc2, Cdc25c, and Cyclin B1) and apoptosis - associated (Bax, Bad, Bcl-2, and Bcl-xl) proteins.
|
30674344 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
POLD1 expression levels were evaluated in patients with different neurodegenerative diseases by ELISA, RT-PCR and Western blot analysis.
|
30978525 |
2019 |
|
Neoplasms, Intracranial
|
0.010 |
Biomarker
|
group |
BEFREE |
We further show that inhibition of the splicing regulatory cdc2-like kinases in combination with an ERR-β agonist shifts isoform expression in favor of ERR-β2 and potentiates inhibition of growth and migration in GBM cells and intracranial tumors.-Tiek, D. M., Khatib, S. A., Trepicchio, C. J., Heckler, M. M., Divekar, S. D., Sarkaria, J. N., Glasgow, E., Riggins, R. B. Estrogen-related receptor β activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma.
|
31570001 |
2019 |
|
Alzheimer disease, familial, type 3
|
0.010 |
Biomarker
|
disease |
BEFREE |
POLD1 deficiency is involved in cognitive function impairment in AD patients and SAMP8 mice.
|
30978525 |
2019 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased cDC2 numbers due to CD11c-restricted Wnt4 deficiency increased IL-5 production, group 2 innate lymphoid cell expansion, and host resistance to the hookworm parasite <i>Nippostrongylus brasiliensis</i> Collectively, these data uncover a novel and unexpected role for Wnt4 in cDC subset differentiation and type 2 immunity.
|
31175162 |
2019 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, POLD1 and MCM2 were found to be regulated by miR-520H via E2F1.High expression of POLD1, MCM2, and PLK4 might play positive roles in the recurrence of ALL, and could serve as potential therapeutic targets for the treatment of relapsed ALL.
|
29768346 |
2018 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, POLD1 and MCM2 were found to be regulated by miR-520H via E2F1.High expression of POLD1, MCM2, and PLK4 might play positive roles in the recurrence of ALL, and could serve as potential therapeutic targets for the treatment of relapsed ALL.
|
29768346 |
2018 |
|
Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR and confocal microscopy revealed that epicardial EPO treatment enhanced levels of intracardiac regenerative key indicators (SDF-1, CXCR4, CD34, Bcl-2, cyclin D1, Cdc2 and MMP2), induced transforming growth factor β (TGF-β)/WNT signaling in intramyocardial MSC niches through the direct activation of AKT and upregulation of upstream signals FOS and Fzd7, and augmented intracardiac mesenchymal proliferation 24 h after MI.
|
29752300 |
2018 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increase of the tumor-node-metastasis (TNM) staging of osteosarcoma and the high expression of CDC2 are the risk factors affecting the prognosis of osteosarcoma patients (P<0.05), and Cox regression analysis showed that the expression level of CDC2 was a risk factor affecting the prognosis of osteosarcoma patients (P<0.05).
|
29731906 |
2018 |
|
Psoriasiform eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functionally, CD301b<sup>+</sup> cDC2 was capable of producing a high level of IL-23, and the depletion of CD301b<sup>+</sup> cDC2 effectively prevented IL-17-mediated psoriasiform dermatitis.
|
29138056 |
2018 |
|
Pleomorphic Xanthoastrocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In post-hoc subgroup analysis, hypermutator tumors (mismatch repair deficiency and somatic POLE/POLD1 mutations) and those biologically resembling pleomorphic xanthoastrocytoma ([PXA]-like, driven by BRAF_V600E or NF1 mutation) had significantly more CD8<sup>+</sup> tumor-infiltrating lymphocytes, and longer survival with the addition of BEV.
|
29763623 |
2018 |
|
Mandibuloacral dysostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A new form of mandibuloacral dysplasia has been recently associated with mutations in POLD1 gene, encoding DNA polymerase delta, a major player in DNA replication.
|
29208544 |
2018 |