|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This might constitute the first step towards identifying polymorphism combinations that predispose to endometriosis (IFNG (CA) repeat, GSTM1 null genotype, GSTP1 rs1695, WNT4 rs16826658 and WNT4 rs2235529) in a large cohort of patients with well-defined inclusion criteria.
|
31821471 |
2020 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1).
|
30194396 |
2018 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.
|
28333195 |
2017 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
|
28537267 |
2017 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated whether single nucleotide polymorphisms (SNPs) rs7521902, rs10859871 and rs11031006, mapping to WNT4, VEZT and FSHB genetic loci, respectively, are associated with risk for endometriosis in a Greek population.
|
28901453 |
2017 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) have identified markers within the WNT4 region on chromosome 1p36.12 showing consistent and strong association with increasing endometriosis risk.
|
28171565 |
2016 |
|
Endometriosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
There were no significant differences between the protein and mRNA expression of WNT4 in ectopic endometrium and in EU from participants with endometriosis.
|
26363035 |
2016 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that rs16826658 and rs3820282 polymorphisms on WNT4 gene might be involved in the pathogenesis of endometriosis in the infertile women studied.
|
26139156 |
2015 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
|
25682310 |
2015 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the rs10965235 SNP in the CDKN2B-AS gene and the rs16826658 SNP near the WNT4 gene were significantly associated with endometriosis in this Korean population.
|
25154675 |
2014 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study link novel loci to endometriosis.
|
23472165 |
2013 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study link novel loci to endometriosis.
|
23472165 |
2013 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We confirm WNT4, CDKN2BAS and FN1 as the first identified common loci for endometriosis.
|
23142796 |
2013 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A SNP, rs16826658, in the LD block including WNT4 on chromosome 1p36, which is considered to play an important role in the development of the female genital tract, revealed a possible association with endometriosis (P = 1.66 x 10(-6), odds ratio = 1.20).
|
20601957 |
2010 |