|
Drug habituation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We clustered genes by similarity in phenomic profiles and used epistasis analysis to discover parallel networks centered on <i>CHD8•chd-7</i> and <i>NLGN3•nlg-1</i> that underlie mechanosensory hyperresponsivity and impaired habituation learning.
|
31754030 |
2020 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In summary, we found NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy.
|
31150649 |
2019 |
|
Genitourinary symptoms
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We report gut symptoms in patients with the autism-associated R451C mutation encoding the neuroligin-3 protein.
|
31119867 |
2019 |
|
Gastrointestinal dysfunction
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3.
|
31119867 |
2019 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In summary, we found NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy.
|
31150649 |
2019 |
|
Neurodevelopmental Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our report of two missense variants affecting the normal localization of NLGN3 in a total of five affected individuals reinforces the involvement of the NLGN3 gene in a neurodevelopmental disorder characterized by ID and ASD.
|
31184401 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In summary, we found NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy.
|
31150649 |
2019 |
|
Extracranial Solid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neuroblastoma is the most common extracranial solid tumor of childhood, previous studies show synaptic protein neuroligin-3 (NLGN3) promotes glioma proliferation and growth, However, no investigation about the role of NLGN3 in neuroblastoma was reported.
|
31150649 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of NLGN3 in regulating depression in mice was confirmed in vitro using astrocytes stimulated by LPS that NLGN3 knockdown reduced LPS-induced inflammation.
|
29775613 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of NLGN3 in regulating depression in mice was confirmed in vitro using astrocytes stimulated by LPS that NLGN3 knockdown reduced LPS-induced inflammation.
|
29775613 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a series of validation experiments, we tested mice with different pathologies, including neuroligin-3 deficient mice (male Nlgn3<sup>y/-</sup> and female Nlgn3<sup>+/-</sup>) for autistic behavior, oligodendrocyte-specific erythropoietin receptor knockout (oEpoR<sup>-/-</sup>) mice for cognitive impairment, as well as mouse models of renal failure (unilateral ureteral obstruction and 5/6 nephrectomy) and of type 2 diabetes (ApoE<sup>-/-</sup>) - for delineating potentially confounding effects of motivational factors (thirst, glucose-craving) on learning and memory assessments.
|
29474958 |
2018 |
|
Hirschsprung Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Several SNPs were significantly associated with altered risk of HD in the Chinese Han population, including rs1421589 within <i>NRXN1</i>, rs11795613 and rs4844285 within <i>NLGN3,</i> as well as rs5961397, rs7157669 and rs724373 within <i>NLGX4X</i> (all P<0.05).
|
29622757 |
2018 |
|
Kidney Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a series of validation experiments, we tested mice with different pathologies, including neuroligin-3 deficient mice (male Nlgn3<sup>y/-</sup> and female Nlgn3<sup>+/-</sup>) for autistic behavior, oligodendrocyte-specific erythropoietin receptor knockout (oEpoR<sup>-/-</sup>) mice for cognitive impairment, as well as mouse models of renal failure (unilateral ureteral obstruction and 5/6 nephrectomy) and of type 2 diabetes (ApoE<sup>-/-</sup>) - for delineating potentially confounding effects of motivational factors (thirst, glucose-craving) on learning and memory assessments.
|
29474958 |
2018 |
|
Ureteral obstruction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In a series of validation experiments, we tested mice with different pathologies, including neuroligin-3 deficient mice (male Nlgn3<sup>y/-</sup> and female Nlgn3<sup>+/-</sup>) for autistic behavior, oligodendrocyte-specific erythropoietin receptor knockout (oEpoR<sup>-/-</sup>) mice for cognitive impairment, as well as mouse models of renal failure (unilateral ureteral obstruction and 5/6 nephrectomy) and of type 2 diabetes (ApoE<sup>-/-</sup>) - for delineating potentially confounding effects of motivational factors (thirst, glucose-craving) on learning and memory assessments.
|
29474958 |
2018 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma recurrence correlates with NLGN3 levels.
|
29777576 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma recurrence correlates with NLGN3 levels.
|
29777576 |
2018 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The role of NLGN3 in regulating depression in mice was confirmed in vitro using astrocytes stimulated by LPS that NLGN3 knockdown reduced LPS-induced inflammation.
|
29775613 |
2018 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
An important mechanism that mediates this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synaptic adhesion molecule neuroligin-3 (NLGN3), which promotes glioma proliferation through the PI3K-mTOR pathway.
|
28959975 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
ADAM10 inhibitors prevent the release of NLGN3 into the tumour microenvironment and robustly block HGG xenograft growth.
|
28959975 |
2017 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In humans, mutations in NLGN3 and NLGN4 are linked to autism and schizophrenia; NLGN2 missense variants are implicated in schizophrenia.
|
27865048 |
2017 |
|
Sleep disturbances
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The sleep disruptions in Nlgn3 KO rats are consistent with observations of sleep disturbances in ASD patients.
|
28958035 |
2017 |
|
Social Communication Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The Neuroligin-3 (NL3) mouse, expressing a R451C mutation discovered in two Swedish brothers with ASD, exhibits impaired social interactions and heightened aggressive behavior towards male mice.
|
28255463 |
2017 |
|
Malignant neoplasm of brain
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An important mechanism that mediates this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synaptic adhesion molecule neuroligin-3 (NLGN3), which promotes glioma proliferation through the PI3K-mTOR pathway.
|
28959975 |
2017 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Nlgn3 KO rats were hyperactive, exhibited excessive chewing behavior, and had impaired prepulse inhibition to an auditory startle stimulus.
|
28958035 |
2017 |
|
Malignant Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
|
28959975 |
2017 |