POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE This study sought to examine the protective effects of α-Melanocyte-stimulating hormone (α-MSH) on early diabetic retina against vascular hyperpermeability, electrophysiological dysfunction, and morphological deterioration in a rat model of diabetes and probe the mechanisms underlying the α-MSH's anti-hyperpermeability in both rodent retinas and simian retinal vascular endothelial cells (RF6A). 29402864 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 AlteredExpression group BEFREE At 30 days postdiabetes, ACTH levels remained elevated, whereas cortisol levels decreased compared to the early stage of diabetes. 30256482 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE Selective deletion of LEPR in these neurons with the Cre-loxP system, however, has previously failed to recapitulate, or only marginally recapitulated, the obesity and diabetes that are seen in LEPR-deficient Lepr <sup>db/db</sup> mice, suggesting that AGRP or POMC neurons are not directly required for the effects of leptin in vivo<sup>8-10</sup>. 29670283 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE Since POMC reactivation completely reverses the diabetogenic phenotype, arcuate POMC could be a potential target for diabetes therapy. 30283405 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 AlteredExpression group BEFREE Although basal cortisol and aldosterone levels were similar between them, cortisol levels after the 1-mg DST and the prevalences of diabetes mellitus and proteinuria were significantly higher and ACTH levels and plasma renin activity were significantly lower in cases with ATs than in those without. 31058960 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE The genes at these loci include agouti, which encodes a molecule that antagonizes the binding of alpha melanocyte-stimulating hormone to its receptor; fat, which encodes carboxypeptidase E; tubby, which encodes a putative phosphodiesterase; obese, which encodes a circulating satiety protein; and diabetes, which encodes the receptor for the obese gene product. 8939064 1996
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE Taken together, the observed prediabetes phenotype and lack of response to ACTH indicate that Tspo cKO mice (Nr5a1-Cre<sup>+/-</sup>, Tspo<sup>fl/fl</sup>) could provide a useful model to study the link between diabetes and stress. 30343141 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity. 27623943 2016
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 GeneticVariation group BEFREE We constructed POMC RsaI/C1032G haplotypes, having found no significant association with body mass index (BMI), left ventricle ejection fraction (LVEF), left ventricle hypertrophy (LVH) and diabetes mellitus (DM). 19337797 2009
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE These findings link Cacna1e function to leptin-mediated POMC neuron excitability and glucose homeostasis and may provide a target for the treatment of diabetes. 30304668 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE The adrenocorticotropic hormone in the pituitary gland, adrenocorticotropic hormone receptor, and 11β-hydroxysteroid dehydrogenase in the adrenal gland were all hyper-secreted and expressed from healthy to overt diabetes. 29948652 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group CTD_human Cushing's disease in dogs and humans. 19153526 2009