Depressive disorder
|
0.590 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that in MDD, immune activation is associated with a simultaneous activation of dynorphin/KOR and β-endorphin/MOR signaling and that these opioid systems may participate in the pathophysiology of depression by a) exerting immune regulatory activities attenuating the primary immune response; and b) modulating reward responses and mood as well as emotional and behavioral responses to stress.
|
31753054 |
2020 |
Depressive disorder
|
0.590 |
AlteredExpression
|
disease |
BEFREE |
TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration.
|
31570003 |
2019 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
BEFREE |
Our studies demonstrated that CGA pretreatment ameliorated depression-like behavior (SPT, FST, TST, and OFT) and serum biochemical levels (5-HT, DA, IL-6, and TNF-α) in ACTH-induced depression rats.
|
31073553 |
2019 |
Depressive disorder
|
0.590 |
AlteredExpression
|
disease |
BEFREE |
Increased ACTH level at baseline may predict ongoing symptoms and severity of depression at follow-up, suggesting the role of dysfunctional HPA axis in MDD prognosis.
|
30269042 |
2018 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
BEFREE |
Upon stimulation with ACTH, no adrenocortical depression was observed in any subject.
|
29793605 |
2018 |
Depressive disorder
|
0.590 |
GeneticVariation
|
disease |
BEFREE |
The following search items were used: "hypothalamic-pituitary-adrenal" OR "HPA" OR "cortisol" OR "corticotropin releasing hormone" OR "corticotropin releasing factor" OR "glucocorticoid*" OR "adrenocorticotropic hormone" OR "ACTH" AND "atypical depression" OR "non-atypical depression" OR "melancholic depression" OR "non-melancholic depression" OR "endogenous depression" OR "endogenomorphic depression" OR "non-endogenous depression".
|
29150144 |
2018 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
BEFREE |
Our main findings provide evidence of a dissociation between the cortisol and ACTH concentrations in response to the TSST in PTSD and in PD patients, independent of comorbid depression.
|
28623762 |
2017 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
PSYGENET |
Additionally, at 1, 2, and 8 weeks of treatment, the 21-item Hamilton Depression Rating scores of MDD subjects with POMC ht2 were significantly (P = 0.003-0.044) lower than those of patients with ht1 in subjects those did not experience SLE.
|
25448875 |
2015 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
PSYGENET |
The following depression-related parameters were determined: plasma ACTH, plasma corticosterone, adrenal gland weight and hippocampal levels of brain-derived neurotrophic factor (BDNF).
|
24138845 |
2013 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
PSYGENET |
MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve ACTH and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele.
|
22475622 |
2013 |
Depressive disorder
|
0.590 |
GeneticVariation
|
disease |
BEFREE |
MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve ACTH and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele.
|
22475622 |
2013 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
CTD_human |
Depression scores at SCL-90 in addicted patients positively correlated with plasma ACTH and cortisol values.
|
18201294 |
2008 |
Depressive disorder
|
0.590 |
AlteredExpression
|
disease |
BEFREE |
The demonstration of mRNA POMC in breast carcinoma with NE features suggests a depression and/or an activation of the POMC gene linked to the NE differentiation.
|
15239795 |
2005 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
PSYGENET |
The demonstration of mRNA POMC in breast carcinoma with NE features suggests a depression and/or an activation of the POMC gene linked to the NE differentiation.
|
15239795 |
2005 |
Depressive disorder
|
0.590 |
Biomarker
|
disease |
PSYGENET |
The expression of both CRFR mRNA in the LC and the plasma level of ACTH increased significantly in "depression-model rats" which exhibit reduced activity following exposure to 14 days forced walking stress (FWS), but not in "spontaneous recovery rats" whose activity was restored after the long-term stress.
|
12818721 |
2003 |