POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease PSYGENET The expression of both CRFR mRNA in the LC and the plasma level of ACTH increased significantly in "depression-model rats" which exhibit reduced activity following exposure to 14 days forced walking stress (FWS), but not in "spontaneous recovery rats" whose activity was restored after the long-term stress. 12818721 2003
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 AlteredExpression disease BEFREE The demonstration of mRNA POMC in breast carcinoma with NE features suggests a depression and/or an activation of the POMC gene linked to the NE differentiation. 15239795 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease PSYGENET The demonstration of mRNA POMC in breast carcinoma with NE features suggests a depression and/or an activation of the POMC gene linked to the NE differentiation. 15239795 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease CTD_human Depression scores at SCL-90 in addicted patients positively correlated with plasma ACTH and cortisol values. 18201294 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease PSYGENET MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve ACTH and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele. 22475622 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 GeneticVariation disease BEFREE MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve ACTH and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele. 22475622 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease PSYGENET The following depression-related parameters were determined: plasma ACTH, plasma corticosterone, adrenal gland weight and hippocampal levels of brain-derived neurotrophic factor (BDNF). 24138845 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease PSYGENET Additionally, at 1, 2, and 8 weeks of treatment, the 21-item Hamilton Depression Rating scores of MDD subjects with POMC ht2 were significantly (P = 0.003-0.044) lower than those of patients with ht1 in subjects those did not experience SLE. 25448875 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease BEFREE Our main findings provide evidence of a dissociation between the cortisol and ACTH concentrations in response to the TSST in PTSD and in PD patients, independent of comorbid depression. 28623762 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 GeneticVariation disease BEFREE The following search items were used: "hypothalamic-pituitary-adrenal" OR "HPA" OR "cortisol" OR "corticotropin releasing hormone" OR "corticotropin releasing factor" OR "glucocorticoid*" OR "adrenocorticotropic hormone" OR "ACTH" AND "atypical depression" OR "non-atypical depression" OR "melancholic depression" OR "non-melancholic depression" OR "endogenous depression" OR "endogenomorphic depression" OR "non-endogenous depression". 29150144 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease BEFREE Upon stimulation with ACTH, no adrenocortical depression was observed in any subject. 29793605 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 AlteredExpression disease BEFREE Increased ACTH level at baseline may predict ongoing symptoms and severity of depression at follow-up, suggesting the role of dysfunctional HPA axis in MDD prognosis. 30269042 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease BEFREE Our studies demonstrated that CGA pretreatment ameliorated depression-like behavior (SPT, FST, TST, and OFT) and serum biochemical levels (5-HT, DA, IL-6, and TNF-α) in ACTH-induced depression rats. 31073553 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 AlteredExpression disease BEFREE TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration. 31570003 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker disease BEFREE Our findings suggest that in MDD, immune activation is associated with a simultaneous activation of dynorphin/KOR and β-endorphin/MOR signaling and that these opioid systems may participate in the pathophysiology of depression by a) exerting immune regulatory activities attenuating the primary immune response; and b) modulating reward responses and mood as well as emotional and behavioral responses to stress. 31753054 2020