POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015967
Disease: Fever
Fever
0.330 Biomarker phenotype CTD_human Intraventricular administration of FSH, ACTH or prolactin caused hyperthermia, increased metabolism and/or cutaneous vasoconstriction. 6350720 1983
CUI: C0015967
Disease: Fever
Fever
0.330 AlteredExpression phenotype BEFREE In vivo, recombinant rat IL-1alpha and IL-1beta enhanced body temperature, increased plasma levels of corticosterone and ACTH, and depressed social behaviour. 9831177 1998
CUI: C0015967
Disease: Fever
Fever
0.330 Biomarker phenotype BEFREE <i>In vivo</i>, glucocorticoid release triggered by ACTH might oppose beta-adrenergic stimulation of metabolic fuel combustion in BAT and limit stress-induced hyperthermia. 30705635 2018
CUI: C0015967
Disease: Fever
Fever
0.330 AlteredExpression phenotype BEFREE TonEBP (+/-) mice show reduced sickness responses, which include anorexia and hyperthermia, that are initially induced by tumor necrosis factor (TNF)-α. TonEBP (+/-) mice also show lower levels of TNF-α-induced hypothalamic expression of POMC and pro-inflammatory cytokines. 31281956 2019