POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.330 Biomarker disease BEFREE A Novel Paradigm for Sacubitril/Valsartan: Beta-Endorphin Elevation as a Contributor to Exercise Tolerance Improvement in Rats With Preexisting Heart Failure Induced by Pressure Overload. 30347271 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.330 Biomarker disease BEFREE The patient subsequently developed an ACTH-dependent paraneoplastic Cushing's syndrome and she died of arrhythmia and heart failure, despite treatment. 15239795 2005
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.330 Biomarker disease CTD_human Plasma beta-endorphin levels were elevated in dogs with congestive heart failure. 8277081 1994
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.330 Biomarker disease CTD_human Furthermore, only the animals with CHF responded to the opiate receptor-antagonist nalmefene with significant increases in plasma beta-endorphin, cortisol, and adrenocorticotropic hormone. 3026683 1987
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.330 GeneticVariation disease BEFREE The aim of this study was to investigate the possible associations of defined variability in leptin (dbSNP ID rs7799039), proopiomelanocortin (dbSNP ID rs3754860 and dbSNP ID rs1009388), and leptin receptor gene (dbSNP rs1137101) with CHF and evaluate their potential as the CHF susceptibility genes. 19337797 2009