POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.340 Biomarker disease BEFREE In the current study, we aimed to compare the results obtained with two separate scales, namely the Fatigue Severity Scale (FSS) and the Neurological Fatigue Index-Multiple Sclerosis (NFI-MS), and assess the relationship between fatigue and serum IL-1β, TNF-α, IL-35, IL-2, IL-10, ACTH, cortisol, α-MSH, β-MSH, γ-MSH and CLIP (Corticotropinlike intermediate lobe peptide) in MS patients categorized as fatigued and non-fatigued on the basis of FSS scores. 28641771 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.340 Biomarker disease BEFREE Among MS forms, the highest beta endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest in patients with the progressive forms. 12640071 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.340 Therapeutic disease CTD_human Priapism following olanzapine administration in a patient with multiple sclerosis. 9664777 1998
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.340 Biomarker disease BEFREE This study provided class II evidence that ACTH produced better examiner-assessed cumulative rates of relapses per patient than IVMP in the adjunctive treatment of breakthrough disease in multiple sclerosis. 28450891 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.340 Therapeutic disease CTD_human Nine of 50 MS patients became hypomanic or manic during treatment with ACTH or prednisone. 2843795 1988
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.340 Biomarker disease BEFREE We reported that oligodendroglia (OL) and oligodendroglial precursor cells (OPC) express MC4R, and that ACTH 1-39 protects OL and OPC in vitro from cell death induced by mechanisms likely involved in white matter damage in MS. 28877366 2018