West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
[Treatment of infantile spasms with long-term low dose ACTH].
|
1327015 |
1992 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH) therapy is the first-line therapy for infantile spasms, and is effective for many other intractable epilepsies.
|
25149137 |
2015 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Comparison of efficacies of zonisamide versus adrenocorticotropic hormone was as following: the cessation of epileptic spasms (27% vs. 40%, p = 0.70), resolution of hypsarrhythmia at 14 days (20% vs. 33%, p = 0.68) and resolution of hypsarrhythmia at 6 weeks (36% vs. 71%, p = 0.14).
|
30293931 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Topiramate, levetiracetam, zonisamide, and sodium valproate with benzodiazepine (clonazepam or nitrazepam) were found to be potential drugs for treating West syndrome besides adrenocorticotropic hormone, steroids, and vigabatrin.
|
28288483 |
2017 |
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Cardiac vagal activation by adrenocorticotropic hormone treatment in infants with West syndrome.
|
17287597 |
2007 |
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Images in cardiology. Enlargement of cardiac rhabdomyoma and myocardial ischaemia during corticotropin treatment for infantile spasm.
|
10908253 |
2000 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, AQB-565 may represent a novel treatment of infantile spasms similarly effective as ACTH but with potentially limited side effects.
|
30875634 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
The OR point estimate showed the superiority of adrenocorticotropic hormone over all comparators in infantile spasms.
|
29270989 |
2018 |
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Given the very poor prognosis of infantile spasms especially in such conditions as cerebral palsy, the combination of ACTH and vigabatrin appears to be an interesting therapy advance with very few side effects.
|
8980841 |
1997 |
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
A fatal incident during combined anticonvulsive therapy with ACTH and Dexamethason prompted us to reevaluate our treatment results in 19 children suffering from infantile spasms.
|
2983143 |
1985 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
West Syndrome pharmacological treatment usually consists in antiepileptic drugs and/or ACTH.
|
31724502 |
2019 |
West Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that ACTH(1-24) administrated in West syndrome may influence the expression of neurotrophic factors in astrocytes in vivo.
|
12438675 |
2002 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
In spite of conflicting views as to the long-term effects of ACTH, prompt treatment seems to be mandatory, at least in cryptogenic cases of infantile spasms.
|
6259007 |
1981 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms.
|
31769329 |
2020 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
Cardiac vagal activation by adrenocorticotropic hormone treatment in infants with West syndrome.
|
17287597 |
2007 |
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
In spite of conflicting views as to the long-term effects of ACTH, prompt treatment seems to be mandatory, at least in cryptogenic cases of infantile spasms.
|
6259007 |
1981 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
[Lethal side effects from ACTH-therapy in infantile spasm (author's transl)].
|
6107850 |
1980 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current treatment options include hormonal treatment (adrenocorticotropic hormone and high-dose steroids) and the GABA aminotransferase inhibitor vigabatrin, while ketogenic diet can be given as add-on treatment in refractory IS.
|
28427564 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: A single-center parallel-cohort randomized controlled trial.
|
30801699 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH) is the only medicine for treating infantile spasms, however, it is catabolized rapidly.
|
28127707 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
[Hypertrophic myocardiopathy during the corticotropin treatment of infantile spasms].
|
8928979 |
1996 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
Images in cardiology. Enlargement of cardiac rhabdomyoma and myocardial ischaemia during corticotropin treatment for infantile spasm.
|
10908253 |
2000 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
Renal and pancreatic calcification during treatment of infantile spasms with ACTH.
|
6143199 |
1984 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serial Analysis of Multiple Serum Cytokine Responses to Adrenocorticotropic Hormone Therapy in Patients With West Syndrome.
|
29724126 |
2018 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
The CSF levels of beta-EP and ACTH were significantly lower in patients with IS than those in the controls.
|
11341487 |
2001 |