|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hypertension is a prominent feature of patients with Cushing's disease and ectopic adrenocorticotropic hormone (ACTH) syndrome, who have elevated ACTH levels.
|
11082157 |
2000 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GH secretagogues (GHS) have been used for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS) since 1997 due to their ability to increase ACTH and cortisol levels in Cushing's disease.
|
17556872 |
2007 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Northern blot analysis revealed that the size of pro-opiomelanocortin mRNA present in the SCCA tissue was indistinguishable from that in the adenomas associated with Cushing's disease.
|
2153197 |
1990 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
POMC and Tpit mRNA levels were greater in CD and SCA than those in NFT.
|
18057378 |
2007 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using quantitative real-time PCR, various ACTH-related gene expressions in tumor tissues from CD, subCD, and NFT were measured such as pro-opiomelanocortin (POMC), POMC transcription factor (Tpit, Pitx1, NeuroD1, and Nur77), POMC peptide processing enzymes (prohormone convertase: PC1/3 and PC2), and ACTH secretion-related factors (corticotropin-releasing hormone receptor 1: CRHR1 and glucocorticoid receptor α: GRα).
|
27025408 |
2016 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Higher ACTH levels before treatment predicted a recurrence of CD.
|
28029519 |
2017 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to determine the association of hypokalemia with cortisol and ACTH levels in patients with CD.
|
31456238 |
2020 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, clinical manifestations of CD may vary depending on hormonal activity; however, factors involved in the hormonal aggressiveness of adrenocorticotropic hormone (ACTH)-secreting pituitary tumors have not been fully clarified.
|
30474823 |
2019 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We speculate that the response to the desmopressin test observed in patients with Cushing's disease may be due to abnormal expression of V3R or V2R in ACTH-secreting tumors.
|
8626831 |
1996 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
POMC and Tpit mRNA levels were greater in CD and SCA than those in NFT.
|
18057378 |
2007 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the DDAVP stimulation test, i.e., determination of plasma ACTH levels after 5 microg DDAVP injection, seems useful for discriminating Cushing's disease from normality, and may serve to facilitate the differentiation between Cushing's disease and ectopic ACTH syndrome.
|
9466324 |
1997 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression analysis of a transsphenoidal surgery sample of the pituitary gland revealed that ACTH-related genes, such as POMC, Tpit, and NeuroD1 mRNA, had higher expression in the tumor tissue than the nonfunctional adenoma but lower expression compared to an adenoma of typical Cushing's disease.
|
28865461 |
2017 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of ACTH play a critical role in disease progression in several indications, including congenital adrenal hyperplasia and Cushing disease.
|
27906551 |
2017 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In a patient with full-blown features of Cushing's syndrome with equivocal ACTH levels, and a pituitary microadenoma on contrast-enhanced MRI sella, can falsely lead to a diagnosis of Cushing's disease.
|
28356253 |
2017 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in vivo Bcl-2 protein analysis showed its down-regulation in adrenal hyperplasia of Cushing's disease despite ACTH stimulation.
|
11196462 |
2000 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This can be taken to indicate that mechanisms set into motion by AZA play a role in the regulation of ACTH secretion/POMC expression in tumoral corticotropes and paves the way to further studies in Cushing's disease.
|
24085685 |
2014 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Microadenomas that strongly express POMC were common among mutated tumors, which may lead to the mechanisms by which very small adenomas secrete excess ACTH to present overt CD.
|
26578638 |
2016 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Investigations suggested Cushing's disease; there was suppression after high-dose dexamethasone (<20 nmol/liter) and a 950% increase in ACTH after stimulation with CRH.
|
11788623 |
2002 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
ACTH-secreting pulmonary carcinoids, like the corticotroph adenomas causing Cushing's disease, are often small and difficult to detect, and patients present with a gradual onset of the classical signs and symptoms of Cushing's syndrome, indistinguishable from the presentation of Cushing's disease.
|
29754641 |
2018 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thirteen consecutive patients were diagnosed with Cushing's disease using uncorrected ACTH ratios.
|
28626863 |
2017 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Data obtained by gene array and semi-quantitative RT-PCR showed an increase in the expression of Sp3 and CRSP9 (co-regulator of Sp1 transcription factor, subunit 9) in the adrenal adenomas or bilateral macronodular hyperplasias of patients with GIP-dependent Cushing's syndrome; they were, however, also increased in some patients with non-GIP-dependent cortisol-secreting adenomas or with ACTH-dependent Cushing's disease.
|
16087722 |
2005 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cushing's disease (CD) is the result of excess secretion of adrenocorticotropic hormone (ACTH) by a benign monoclonal pituitary adenoma.
|
27104844 |
2017 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
NEPVs for cortisol and ACTH predicted nonremission after TSS for CD.
|
28323961 |
2017 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cushing's disease (CD) arises from pituitary-dependent glucocorticoid excess due to an ACTH-secreting corticotroph tumor.
|
26012588 |
2015 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
RNA was extracted from adrenal tissues from nine patients with GIP-dependent CS [seven ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH), two adenomas], two control whole adult adrenals, two fasciculata cell-enriched preparations from normal adrenals, seven patients with Cushing's disease (CD) and two normal pancreas.
|
16402925 |
2006 |